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Shingles-Herpes Zoster virus - what antiviral and what dosage and how long ?

Discussion in 'Antivirals, Antibiotics and Immune Modulators' started by raghav, Mar 7, 2018.

  1. raghav

    raghav Senior Member

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    Guys,
    I had shingles (Herpes zoster) virus 35 years back at the base of my spine. The marks are still there. So what antiviral should i try. i googled and found that acyclovir is suitable for this (Cheapest). Or should I try something else ? What dosage and what duration should I be on it ? I dont want to over load my liver and kidneys since I am already on a lot of medications for epilepsy and depression. Please advice. Thx.
     
  2. raghav

    raghav Senior Member

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    If I take famciclovir then what is the daily dosage ?(I am asking this from cost point of view).
     
  3. raghav

    raghav Senior Member

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    @Hip You had prepared a table for the antivirals and the viruses they act upon. I searched but could not find it. Please give me the link to it. Thanks.
     
  4. Hip

    Hip Senior Member

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    You will find that table the roadmap of chronic fatigue syndrome treatment, if you scroll down about one third of the length of the document.
     
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  5. raghav

    raghav Senior Member

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    Hip likes this.
  6. Wonkmonk

    Wonkmonk Senior Member

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    One drug that is not in the road map, but is extremely effective against Varicella Zoster Virus is Brivudine.

    But it's not recommended for use longer than a week because of possible hepatotoxicity (probably that's why it's not in the roadmap). It is used for acute Herpes zoster treatment.

    I used it for 6 weeks with still normal liver tests, but that's of course just me, and it's not recommended for chronic use.

    Also note there is a possibly fatal interaction with some chemotherapeutic agents. Other than that, it has only very few side effects and interactions.

    But it sounds like you need a long-term medication, so it's probably not the first choice anyway.
     
  7. Hip

    Hip Senior Member

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    Because for herpesviruses, ME/CFS is primary linked to EBV, HHV-6 and cytomegalovirus, and brivudine only targets VZV and HSV-1, so it may not be much use in ME/CFS. Although there are some theories that VZV and HSV may be involved in ME/CFS.

    I can't find any instructions or info saying that brivudine is not recommended to be used for more than a week due to hepatotoxicity. Would you have a link to this?
     
    Last edited: Mar 8, 2018
  8. Wonkmonk

    Wonkmonk Senior Member

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    It's from the patient information from the package insert (in German):

    https://beipackzetteln.de/zostex

    "Sie sollten Zostex nicht länger als 7 Tage anwenden, da eine Verlängerung der Behandlung über den empfohlenen Zeitraum von 7 Tagen hinaus mit einem erhöhten Risiko für die Entstehung einer Leberentzündung (Hepatitis) verbunden ist."

    Which means:

    "You should not use Zostex longer for more than 7 days, because treatment of longer than 7 days is associated with an elevated risk for inflammation of the liver (Hepatitis)."
     
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  9. Hip

    Hip Senior Member

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    I have now added brivudine to the roadmap, in the antiviral table and in the varicella treatment section.
     

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