I've always had PMS. Always. I was on the pill for about 3 years, and my PMS was actually worse on the pill than off it (and it was the pill that is supposed to be good for PMDD). I've been off the pill for about 4 years now I think. Fast forward...here comes the PMDD from hell. I never knew what it was until I started experiencing it. The approx. 10 days before my period, I can get: 1.Emotionally unstable to a crazy degree 2. Experience exhaustion so bad I can only make it 10 feet to the bathroom 3. INSOMNIA 4. Crying jags for not reason 5. Feelings of hositility towards a person for no reason at all 6. All my CFS symtoms get way, way worse 7. Knowing that I'm acting or feeling crazy and not being able to do anything about it. Now from what I've been reading it is due to the drop in PROGESTERONE which is accounting for these symptoms, but then I read that they think progesterone could activate XMRV? I don't get why this is happening now, about 6 years into my illness. I am no where near menopause or perimenopause. I used to just get severe PMS and dread my period....now I look forward to getting my period! I also don't get the same degree of PMDD every month. Sometimes it is minor, sometimes severe. If hormones are indeed playing a part in this disease, I wish I knew what if anything I could do to feel better. I did have my hormones tested years back and the only things off was my testosterone was low due to my being on the pill.....I took topical testosterone (probably really dumb idea now) for a few months, after that everything was OK. If progesterone is involved in XMRV and then probably other viruses such as EBV,hhv-6, etc., wouldn't one feel BETTER when their progesterone is low? Ugh, so confused!