Does anyone have any ideas on what might be causing a problem I've been having for about a year now, which is worsening to the point that now I'm in a wheelchair much of the time? I've been having pain in my thighs, mostly in the front but also on the sides and in the back when it rains. Sometimes my hips and knees hurt too. My massage therapist who is a trigger point specialist and myotherapist says the fascia feels very unusual, like pleated bubble wrap, and the muscles (quads, IT bands) also feel very lumpy and weak. Massage therapy is not working as expected. The pain is constant and severe, and can escalate to full blown pain crisis. There is progressive weakness too which may be from deconditioning since I can't walk when the pain is out of control but I can walk somewhat better when I have good pain control which is rare. Extreme heat seems to relieve the pain somewhat. A compression garment like long spanx helps too, and may be the most helpful thing I've tried so far. Flexeril seems to help a little. The pain is always a deep sickening ache, sometimes there are sharp stabbing pains, some places burn sometimes, and it often feels like my legs are crushed under a heavy object like a car. I've lost 18 lbs in the last 6 month while mostly in bed, since I don't have much appetite due to the pain. It's very puzzling, distressing and depressing at times. I had a lumbar and pelvic MRI which were normal. Nerve conduction studies were mostly normal. Lots of labs have been done, with nothing remarkable showing up. I was tested for Lyme, and was positive first then negative by Western blot. Anybody got any ideas? I'm stumped, so are the docs I have seen, although none of them will actually palpate my legs and feel these knots and lumps. Ideas anyone?