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Serotonin the new 'Cure All'

Discussion in 'General ME/CFS Discussion' started by heapsreal, Jun 12, 2014.

  1. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    i reckon seroquel is like a brake for your brain or a reset button. it effects a few neurotransmitters that make it sedating.
  2. minkeygirl

    minkeygirl Senior Member

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    @heapsreal, so that means the methylation supplements do something to the neurotransmitters? Well, I'm just glad there's a reason why I'm angry all the time besides just inflammation and being a bitch! :)

    The Seroquel saved me for the most part. I can feel my brain is better.
    heapsreal likes this.
  3. Leopardtail

    Leopardtail Senior Member

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    You are pretty much spot on heaps, it hinders the effect of a wide range of Neurotransmitters. Basically it's a med for extreme anger or Anxiety, but could cause a whole bunch of trouble with normal or low Neurotransmitter levels, or with in imbalance of them. There have been lawsuits around it.
    heapsreal likes this.
  4. Leopardtail

    Leopardtail Senior Member

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    yes Minkey, methylation is involved in Neurotransmitters in various ways.
    If you are taking any form or re-uptake inhibitor or mood enhancer for example the dose should be discussed with your doctor, you can end up with Neurotransmitter toxicity due to excessive levels.
  5. minkeygirl

    minkeygirl Senior Member

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    I've never been able to take any "brain" meds without problems. I forgot to take the seroquel last night and I'm really noticing a difference. Those 25 mgs help a lot.

    I know it first came out for Bi-polar disorder.

    The doc who gave me the seroquel is clueless about methylation and ME. I'm taking 25 mgs so I should be ok.

    I'll discuss it with my NP next month.
  6. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    I find it great for sleep and is good when in a bad cycle of insomnia, thats when it resets everything.

    But if i use it regularly i find my muscles and joints get stiff and sore, more then usual. i think this might be from lowering dopamine too much. I have used dopa macuna after a seroquel sleep and it has eased the muscle and joint pains some??

    So i dont use it unless i really need to, plus traditional sleep meds still help. I dont know if its because i take a night off benzos when i use seroquel or if its something else but i find my benzo sleep meds work better after a night on seroquel??

    I havent noticed any long term side effects but maybe using low doses(12.5mg -50/100mg) used infrequently is the key??
  7. minkeygirl

    minkeygirl Senior Member

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    I noticed a big difference in my brain today by not taking Italy night. I wasn't as angry as I had been but i could tell feel the difference in my brain.

    I'm taking 25 Mgs (about) Becuase I'm splitting 100 Mgs so less may work too. I'll see when I get a refill.
    heapsreal likes this.
  8. Martial

    Martial Senior Member

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    I can't say for how long it lasts, I didn't take any meds to compensate for it but I had to be sure not to go off on someone when it was happening myself LOL. It is definitely a common thing with methylation and just takes time and it fades when everything else comes back online, I got all kinds of weird emotional/psychiatric symptoms from startin g methylation. Niacin can help a ton, alongside being sure to have enough magnesium and just letting it pass through. Seroquel might have helped by making your emotions blunted, though I would be careful with anti psychotic drugs like that one.
  9. minkeygirl

    minkeygirl Senior Member

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    I had brain issues long before methylation and I've felt for a long time that I needed something. It was just a happy accident that the Seroquel helps me. At 25 mgs I'm not worried about it and the benefit I get right now is huge. Not just the anger, which was a nightmare but I feel calmer and less out of control. My senses aren't numbed at all, I just feel more level.

    I forgot to take it Friday night and I felt really off so I'm staying on it because even after I get past the problems with methylation that would still leave me with the other issues.
  10. Martial

    Martial Senior Member

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    well thats a low dose, and that sounds fine minkey, whatever helps you sounds like it could be very therapeutic :D I have major brain issues too, just did a brain health test at my doctors which proved major impairment of electrical communication and the like.. My memory and learning were in the red, my reaction times and recognition levels were off the charts high though, so basically my long term memory/brain is effed.. LOL for now at least..
  11. minkeygirl

    minkeygirl Senior Member

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    I'm not talking about memory issues, more about brain function. Like I said, I've known something has been off for a long time, I just wasn't sure which way to go because I've had horrible reactions to other things that work specifically on the brain.

    Years ago there was a psychologist Linda Miller-Iger who used the MMPI to diagnose CFS. I went through the testing and she told me my brain functioned at the level of a 5th grader. Add my other stuff (family history of mental issues) and I'm toast.
  12. minkeygirl

    minkeygirl Senior Member

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    What's interesting is just talking about this is pissing me off! Lol
    rosie26 and heapsreal like this.
  13. minkeygirl

    minkeygirl Senior Member

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    @Martial I just remembered you said to take niacin when feeling bad. . I thought I read that niacin stops the methylation process.

    Did I read it wrong? Where am I confused?
  14. knackers323

    knackers323 Senior Member

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    Anyone know what happened to the two biovista serotonin drugs that were meant to be so promising?
    catly likes this.
  15. catly

    catly Senior Member

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    outside of NYC
  16. Leopardtail

    Leopardtail Senior Member

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    what's akasthesia?
  17. Leopardtail

    Leopardtail Senior Member

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    Whole bunch of problems can cause pain - not expert enough on pain to pick my way through it. I do know both dopamine and serotonin are involved in pain.
  18. justy

    justy Senior Member

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    http://www.breggin.com/31-49.pdf

    Akathisia typically goes away when the drug is stopped, however my extreme agitation and anxiety continued for over two years after cessation of the drug and my anxiety issues have never completely resolved. I developed Agoraphobia and now of course what with being relatively housebound with moderate M.E its pretty impossible to challenge the agoraphobia by a programme of desensitisation ie going out repeatedly until it feels normal. I have received treatment for this, but of course when a therapist tells you you have nothing to fear this is not true when you have M.E and cant go out without a wheelchair or someone to drive you.

    I'm just hoping that if I get treatment for the M.E and it improves I can then deal with the other issues.
  19. adreno

    adreno 3% neanderthal

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    http://www.psychiatrictimes.com/sleep-disorders/effects-antidepressants-sleep
  20. minkeygirl

    minkeygirl Senior Member

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    @justy can you say which SSRI?

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