New era for ME/CFS research as top cytokine study attracts media headlines
The immune systems of patients who have recently developed ME/CFS look markedly different from those who have been ill for much longer, according to a major new study from Drs. Ian Lipkin and Mady Hornig at Columbia University. This shift in immune function hadn’t been seen before.
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Sensory characterization of somatic parietal tissues in humans with CFS (1996)

Discussion in 'Latest ME/CFS Research' started by Dolphin, Aug 18, 2011.

  1. Dolphin

    Dolphin Senior Member

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    Another Italian muscle study where I probably won't be able to contribute much but thought I'd post as I found it interesting and also it doesn't seem to have got much attention:


     
  2. mellster

    mellster Marco

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    Spot on again, nice find, thanks! Explains the muscle-twitching and lowered sensory pain threshold.
     
  3. valentinelynx

    valentinelynx Senior Member

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    "Thresholds in patients were normal in skin and subcutis but significantly lower than normal (hyperalgesia) in muscles (P < 0.001) in all sites."

    I am surprised at this finding: not about hyperalgesia in muscle tissue but at the lack of it in skin and subcutaneous tissue. In my experience, skin hypersensitivity and even allodynia (pain from light touch or a touch that should not normally elicit pain) is common, and I believe this is a commonly cited symptom of ME as well. I am not so certain about the idea that all painful stimuli are amplified (for example, I still enjoy spicy food) but skin hypersensitivity is definitely a symptom.
     
  4. Mark

    Mark Acting CEO

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    I personally found that striking as well, valentinelynx, since skin hypersensitivity is a core symptom for me, and I was struck by finding so many people here on the forums who have that as well. I'm not sure what the percentages are though, and thanks to the confused and widened definitions of ME, and the lack of research, it's difficult to be confident how common that symptom really is. Personally, I suspect that we are a subset, albeit with lots of other features in common with the rest of ME - and maybe this research just had a cohort (of 21 'CFS' patients) that didn't include us.

    Regarding skin hypersensitivity and allodynia, I'm still optimistic about a recent paper on eczema - "Tight junction defects in atopic dermatitis" (PMID 21163515) - which suggests (very roughly) that certain immune deficiencies can cause a collapse of the protective 'tight junction' layer underneath the skin; this also affects the lining of stomach and intestines, and the ear canal as well I think. In eczema there's an additional deficiency in the skin, but for my own skin hypersensitivity this finding sounds like it makes a lot of sense.
     

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