I never had problems with being sensitive/overreactive to anything until I developed CFS 11 years ago. Now it seems like every time I research something that sounds like it might help me, my body rejects it! I wonder why, and what I might be able to do in order to better tolerate things that would be good for me. Just a quick bit of info. I'm on the Paleolithic diet and doing well; it suits me. Since I started that and stuck to it 3 months ago, my reactiveness to various foods has disappeared. (At first I couldn't even have the odd 'treat' of something sugary or bready because it would make all my symptoms worse, but now it's not a problem.) That's the good news, anyway. I supplement with the following: Vitamin C (18g a day - my main supplement), Vitamin D3, Vitamin B complex, krill oil, magnesium (citrate), ginko biloba, ashwagandha, Himalayan sea salt, psyllium husk. This is a tried-and-tested regime I developed over a number of years, a core of things that really help me. I've tried lots and lots of other things that either had no effect, made me feel worse, or that worked for me once but no longer do. Some examples: B12 (oral methylcobalamin), zinc, chromium, vitamin E (mixed tocopherols), Garden of Life multi, liquorice root, colloidal silver, colloidal minerals, adrenal glandular supplement . . . and on and on. Lately I have tried very hard to take olive leaf extract and Lauricidin (monolaurin) but could not tolerate the smallest amount. Well actually, I can't seem to win with the Lauricidin at the moment, because it's clearly giving me something I need, despite that fact that even one grain overstimulates my system and makes some other symptoms worse. When I stop taking it, I feel worse still. I can only hope my body will get used to it gradually, but it doesn't seem to be happening so far. I started looking into the possibility of methylation problems, since I also am now alcohol intolerant. But when I took one dose of milk thistle, I felt bowled over and got heart palpitations. I don't believe my reactivity to these supplements is a herx; that seems to be the immediate go-to explanation when the body has difficulty with a supplement, but my symptoms don't match those of a herx, they stay the same rather than fluctuating, and they don't go away. When I was seeing a herbalist several years ago I did some detoxing under her instructions as well, which involved parasite and candida cleanses and a liver flush, and I felt no different, which would suggest that if my ability to detox is compromised, it's perhaps not too bad - but then, who knows? It's frustrating when I can't take things that I believe would help me to feel better. Does anyone know of an avenue I might explore, or is this simply something I will have to deal with/work around?