I have a two-fold question. Firstly, I was wondering if people here found that their sensitivities to medications like anti-depressants, stimulants etc. *increased* after they became ill? I can't really recall if it's always been the case for me, i.e. if it's something that's genetic, or if it's developed over time, but I've become cripplingly sensitive to psychiatric drugs and experience a lot of paradoxical reactions therein. Secondly, did getting your anxiety/depression under control by some means (e.g. on an SSRI) *alter* your sensitivity to other drugs, i.e. did it allow you to tolerate benzos or other stuff that had previously caused you trouble? The reason I'm asking is because my OCD is pretty out-of-control, to the point where I don't know how much longer I can take it. I was heartbroken when two drugs that had showed pretty inspiring results in studies -- Memantine and Riluzole -- both made me feel far worse. I've been wondering lately if revisiting either with something like an SSRI on board would be worthwhile. Thanks!