As an alchemist, there is "perpetual change" all the time. That is in the world of our souls. "Trial by illness" and "Trial by Death" are things that one may experience and be transformed. There are years of work involved to get started and then it is a way of life, a way of "eternal" life some would say. A non dualist finds ones highest identity in the Absolute. The nature of change as one progresses is predictable in certain ways and changes the nature of the self. The change is one of allowing more of the "energy" (Kundalini or whatever one wants to call such energies) to flow and to be information. This flow between persons is Shaktipat. That all becomes normal enough The "feeling" of different, not normal, because of changing symptoms of illnesses or healing of them is different from the energy changes of alchemy though there can be some crossover of feeling. One man I taught for some years put forth the idea that each person is doing quite literally the best they know how. We might not understand their understanding that leads them that specific "doing", we might not agree with it. We also don't know what effects what they are doing has on their being which the purpose of the whole process. The price is high; all ones hopes and dreams, fears and nightmares, all of ones fantasies and wishes and ignorance. And in the "way of ordinary life" it is the challenges of ordinary life that provides the context.