Found by accident mostly, that selenium (as in food supplement type) has really helped me in last couple of weeks 1) had ME/CFS for about 16 years, "medium severity" I'd say currently on (prescribed) testosterone via nebido injections (due to pituitary not producing testosterone controlling hormone), Tylex and Gabapanetin (pain) 2) Exploring possibility that having a mouth full of amalgam fillings, and having lived next to one of the world's biggest and most polluting steelworks, I thought I'd try selenium, as it's an antidote for mercury and several other heavy metal poisons however, selenium itself is extremely toxic, so just stuck to the standard single tablet per day. it seemed ot help, however, this year I have been extremely ill by comparison to prior year, probably because UK has had such terribly cold weather, which makes me worse, and prior year was very warm. So I forgot to take the selenium, my health etc was worse. 3) Around week or two afore Christmas I started taking selenium again and I accidentally took one tablet too many next day I felt much better, at least in regards to mood. So last couple of weeks I've been taking two or three selenium tablets a day, and noticed a very good improvement in some aspects of my experience and mood I do not know if it is the ME/CFS itself, or the testosterone or something else, but over past few years I have found that I have had increasing nerve pain, and discomfort. Best way I can describe it is like this: a) A wind up clockwork key inserted into base of neck, turned tighter and tigher, winding you until you feel like you will snap I do not mean a LITERAL key, but merely to explain the horrible sensation of being wound up like a spring about to snap in both terms of mood and nerves, ick! b) sensation like "nails scratching down a blackboard", but down back of my brain and rearwards/upper back, down the nerves. the selenium seems ot have calmed those effects, making my mood much better, as they were making me extremely irritable A shower/bath also helps those, to an extenet but not for such duration and "style" (can't explain it easily) Also, due to circumstances I have had to change from a bath to a shower in my home, and while showers do certianly help reduce the muscle pain and discomfort, they aren't as good as a bath. I also often dip/wash my hands in hot water, as they, along with my upper arms, are especially painful. I suspect this is because I use the computer so much. Feels like I've been punching a brick wall But why does hot water reduce the pain/discomfort from ME/CFS so much??