Based on the actual research, VDR Bsm is reported backwards, hence you have the "good" version. There's no research anywhere showing that BHMT-02 or BHMT-04 are a problem. BHMT-08 does affect gene functioning, but to a minor extent - maybe a couple percentage points. MAO also has some impact, but studies have phrased it as the G allele resulting in the gene being more active in certain mental illness - I haven't seen anything indicating that the slower version (I presume you have T/TT) is a problem. T/TT is also an extremely common genotype - around 50% of the population has it. So based on the studies I have access to, T/TT is probably the preferable/safer version. MTHFR A1298C is the only one which is relatively serious. Functionality of the gene might be down to 75% or less. So supplementing active folate is the only real suggestion I've got for you based on those Neither version of COMT V158M or H62H can really be considered bad or good. Like with MAO there's faster or slower degradation of catecholamines. Being heterozygous is just a matter of being in the middle of the scale, instead of leaning to one side - there doesn't seem to be any risk factor associated with it. At most I'd say that your catocholamines don't break down quickly, so doing anything to increase or enhance them might be unpleasant. While MTRR A66G can have some effect, the heterozygous version doesn't show a statistically significant effect. SHMT1 C1420T probably doesn't have a direct impact itself, but can increase the effect of MTHFR C677T. You don't have that MTHFR, so nothing to worry about there. SUMMARY: Your active folate levels might be low, so it's possible that supplementing an active form of it will be helpful. Some people need to avoid artificial folic acid to benefit from folate, but no idea if you're one of them. Be careful if doing anything that might increase levels of dopamine, norepinephrine (noradrenaline), epinephrine (adrenaline), and/or serotonin. Some people also think MAO/COMT problems are a good reason to avoid supplementing high doses of methyl sources (mega doses of B12 or methylfolate), but no idea how accurate that is.