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Screening NK-, B- and T-cell phenotype and function in patients suffering from Chronic Fatigue Syndr

Discussion in 'Latest ME/CFS Research' started by lansbergen, Mar 23, 2013.

  1. lansbergen

    lansbergen Senior Member

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    I concluded decades ago something was wrong with Tcell function.

    Levamisole improves Tcell function.
    sianrecovery and heapsreal like this.
  2. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    Very similar finding to bond uni/PHANU in australia
  3. lansbergen

    lansbergen Senior Member

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    Do you have a link?
  4. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    http://www.translational-medicine.com/content/pdf/1479-5876-9-81.pdf

    Abstract

    Background:

    Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) is characterised by severe prolonged

    fatigue, and decreases in cognition and other physiological functions, resulting in severe loss of quality of life,

    difficult clinical management and high costs to the health care system. To date there is no proven

    pathomechanism to satisfactorily explain this disorder. Studies have identified abnormalities in immune function

    but these data are inconsistent. We investigated the profile of markers of immune function (including novel

    markers) in CFS/ME patients.

    Methods:
    We included 95 CFS/ME patients and 50 healthy controls. All participants were assessed on natural killer

    (NK) and CD8
    +T cell cytotoxic activities, Th1 and Th2 cytokine profile of CD4+T cells, expression of vasoactive

    intestinal peptide receptor 2 (VPACR2), levels of NK phenotypes (CD56
    bright and CD56dim) and regulatory T cells

    expressing FoxP3 transcription factor.

    Results:
    Compared to healthy individuals, CFS/ME patients displayed significant increases in IL-10, IFN-g, TNF-a,

    CD4
    +CD25+ T cells, FoxP3 and VPACR2 expression. Cytotoxic activity of NK and CD8+T cells and NK phenotypes, in

    particular the CD56
    bright NK cells were significantly decreased in CFS/ME patients. Additionally granzyme A and

    granzyme K expression were reduced while expression levels of perforin were significantly increased in the CFS/ME

    population relative to the control population. These data suggest significant dysregulation of the immune system

    in CFS/ME patients.

    Conclusions:
    Our study found immunological abnormalities which may serve as biomarkers in CFS/ME patients

    with potential for an application as a diagnostic tool.
  5. lansbergen

    lansbergen Senior Member

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    I always said part of the immune system fails and another part goes in overdrive to try to compensate for that.
    SOC, sianrecovery and heapsreal like this.
  6. Hmm, makes me wonder that if the success of Rituximab is less attributable to the lack of B-cells post treatment but rather the way T-cells are forced to function in the absence of B-cells.

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