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Scientists post open letter to Lancet on Virology Blog - call for independent re-analysis of PACE

Discussion in 'General ME/CFS News' started by Sasha, Nov 13, 2015.

  1. Sasha

    Sasha Fine, thank you

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  2. Sasha

    Sasha Fine, thank you

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    I'm not kidding, I've got tears in my eyes.

    I'm so grateful to the signatories:

    Ronald W. Davis, PhD
    Professor of Biochemistry and Genetics
    Stanford University

    Jonathan C.W. Edwards, MD
    Emeritus Professor of Medicine
    University College London

    Leonard A. Jason, PhD
    Professor of Psychology
    DePaul University

    Bruce Levin, PhD
    Professor of Biostatistics
    Columbia University

    Vincent R. Racaniello, PhD
    Professor of Microbiology and Immunology
    Columbia University

    Arthur L. Reingold, MD
    Professor of Epidemiology
    University of California, Berkeley

    Thank you so much, @Jonathan Edwards.
     
    Mary, MEMum, Mel9 and 46 others like this.
  3. Cheshire

    Cheshire Senior Member

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    Mary, justy, beaker and 20 others like this.
  4. Gijs

    Gijs Senior Member

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    Thank you all for this incredible review of flaws. I have studied statistics. From my perspective i suspect severe bias and different outcomes.
     
    justy, maryb, Jennifer J and 2 others like this.
  5. Sasha

    Sasha Fine, thank you

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    That blog takes comments, BTW, and I think it would be great if people expressed their appreciation there.
     
    MEMum, justy, MeSci and 5 others like this.
  6. snowathlete

    snowathlete having a NICE day for once

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    Brilliant, nice and concise.
     
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  7. Denise

    Denise Senior Member

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    This is a great letter and I appreciate those who wrote and signed it.

    Was it posted solely on the Virology blog or was it also sent to Dr. Horton and Lancet?
     
  8. Countrygirl

    Countrygirl ME is not MUS

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    Excellent! Thank you to all concerned.

    After 40 years, the above is a gross understatement, but you should see the comment I wrote in rough! It was just too emotional after all these years of medical negligence, misunderstanding, insults and outright abuse to post.
     
    MEMum, CantThink, moosie and 11 others like this.
  9. Sasha

    Sasha Fine, thank you

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    I don't know but I would imagine they've sent a copy - wouldn't be much point, otherwise. :)
     
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  10. Wildcat

    Wildcat

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    Its an Open Letter to Richard Horton, Editor of the Lancet, and The Lancet.

    Richard Horton can hardly ignore it.
     
    Last edited: Nov 13, 2015
    justy and catly like this.
  11. richio76

    richio76

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    Great letter. It'll be ignored, of course, but it could hopefully draw more like minds out of the woodwork. Only so many voices can be dismissed. Thank you to @Jonathan Edwards and the others involved.
     
    Mary, MEMum, moosie and 6 others like this.
  12. Daisymay

    Daisymay Senior Member

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    AMAZING!

    Thank you so very, very much to all the signatories, thanks Prof Edwards!
     
    MEMum, moosie, MeSci and 4 others like this.
  13. Denise

    Denise Senior Member

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    I very much hope they have sent it but it wasn't clear to me on the blog, if they had.
    Occupy CFS seems to indicate that the letter has been sent.
    I hope that is the case because while blogs appear to be monitored by all sorts of organizations/people, I don't think one can assume that Lancet or Dr. Horton do. So actually sending a letter would seem to give a better chance of it being read by them.
     
    MeSci likes this.
  14. Esther12

    Esther12 Senior Member

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    We'll see. Horton is in pretty deep with PACE. He might still be hoping he can get away with ignoring the problems even if it means making the Lancet look even worse.
     
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  15. DeGenesis

    DeGenesis Senior Member

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    A quote I'm sure most of you are familiar with.

    "The case against science is straightforward: much of the
    scientific literature, perhaps half, may simply be untrue.
    Afflicted by studies with small sample sizes, tiny effects,
    invalid exploratory analyses, and flagrant conflicts
    of interest, together with an obsession for pursuing
    fashionable trends of dubious importance, science has
    taken a turn towards darkness. As one participant put
    it, “poor methods get results”.

    - Richard Horton

    I wasn't familiar with his article. My mom brought it to my attention after reading it in our local newspaper.

    I haven't been following this saga, so I don't know Dr. Horton's disposition. I can only hope that he takes his own words seriously.
     
    Mary, MEMum, CantThink and 17 others like this.
  16. Marco

    Marco Grrrrrrr!

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    Near Cognac, France
    catly likes this.
  17. Jonathan Edwards

    Jonathan Edwards Senior Member

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    Well I would say that's Mornington Crescent isn't it?

    At least it is something to relish.
     
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  18. charles shepherd

    charles shepherd Senior Member

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    This is excellent

    However, it's worth noting that many of these key points have already been raised in previous correspondence relating to previous PACE trial papers.

    Eg the letters to the editor that followed the first paper on 'recovery' following PACE trial interventions

    http://www.meassociation.org.uk/.../pace-trial-letters.../

    These criticisms were very firmly dismissed by the authors and by the Lancet.

    So we are still on an uphill struggle...
     
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  19. charles shepherd

    charles shepherd Senior Member

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    This is the full comment piece from Richard Horton

    http://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(15)60696-1.pdf

    Would be interesting to know roughly what percentage of research that is published in The Lancet would fit this description!
     
    MEMum, justy, Never Give Up and 7 others like this.
  20. Sasha

    Sasha Fine, thank you

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    But what's new is that it's big-name scientists who are saying it and it's not buried in the correspondence column of The Lancet - and therefore not under the control of The Lancet.

    I think it's important to recognise when things have stepped up a gear!
     
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