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Scientists identify explanation for non-coeliac gluten sensitivity (relevant to ME)

Discussion in 'Other Health News and Research' started by Cheesus, Aug 11, 2016.

  1. Cheesus

    Cheesus Senior Member

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    This will probably come as absolutely no surprise whatsoever to anyone on the forum.

    Remind anyone of a compelling hypothesis currently under investigation in a certain disease?

    Full article:
    https://www.sciencedaily.com/releases/2016/07/160726123632.htm
     
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  2. A.B.

    A.B. Senior Member

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  3. Skippa

    Skippa Senior Member

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    Is there a test for this sort of thing?
     
  4. Cheesus

    Cheesus Senior Member

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    Last edited: Aug 11, 2016
  5. Cheesus

    Cheesus Senior Member

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    Kind of. You can get a leaky gut test from Cyrex that will look at immune reactivity to intestinal antigens such as lipopolysaccharide:

    http://www.cyrexlabs.com/CyrexTestsArrays (array 2)

    But we can't at this stage say whether or not that is what is making you ill.
     
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  6. A.B.

    A.B. Senior Member

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    Source http://grantome.com/grant/NIH/R21-AI121996-01
     
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  7. Cheesus

    Cheesus Senior Member

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    The pieces of the puzzle are falling into place. Let's hope the image we think we're seeing turns out to be accurate, as that would presumably result in relatively straightforward and safe treatment options.
     
  8. Thinktank

    Thinktank Senior Member

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    There are several tests that i can think of that might indicate a leaky gut and gut dysbiosis.

    1. Lactulose/mannitol test
    2. Soluble CD14
    3. IgA against certain gut bacteria
    4. Zonulin (in the case of gluten sensitivity)
    5. PCR DNA stooltest like Ubiome, not directly proof of a leaky gut but dysbiosis may lead to a leaky gut
    6. IgG against certain foods aka food sensitivities.
     
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  9. Hip

    Hip Senior Member

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    Looks like to be along the same lines of the pioneering work by Dr Alessio Fasano, who investigated the difference between gluten sensitivity in those with celiac disease, and non-celiac gluten sensitivity (ie, a food intolerance to gluten).

    It turns out that in non-celiac gluten sensitivity, the innate immune system targets and attacks the gluten in the intestines, leading to inflammation both inside and outside the digestive system. Whereas in celiac gluten sensitivity, this immune attack involves both the innate immune system and the adaptive immune system responding to gluten.

    It is the adaptive immune system that is behind autoimmune disease, and in celiac disease, gluten causes the adaptive immune system to mount an autoimmune attack on the intestines, leading to intestinal damage (specifically, destruction of the villi of the small intestine).

    In non-celiac gluten sensitivity, because the adaptive immune system is not involved, there is no intestinal damage. Although Dr Fasano says non-celiac gluten sensitivity can produce near-identical symptoms to celiac, including diarrhea, bloating, abdominal pain, joint pain, depression, brain fog and migraines.
     
    Last edited: Aug 12, 2016
  10. Cheesus

    Cheesus Senior Member

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    Just to warn anyone thinking of doing a Lactulose/Mannitol test: it is only specific to the small intestine. It will not tell you if you have colonic permeability. If you want to test for permeability of both intestines then it is better to use a polyethylene glycol test.

    The Cyrex Array 2 includes testing for zonulin, I believe.
     
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  11. Skippa

    Skippa Senior Member

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    Won't everyone have some degree of permeability?

    So, does being positive for one of these tests definitely have medical significance?

    And then what? What does a permeable gut mean... How does one take immediate steps to manage it?
     

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