Discussion in 'Other Health News and Research' started by hixxy, Apr 8, 2017.
Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma
Kenneth Verstraete, Frank Peelman, Harald Braun, Juan Lopez, Dries Van Rompaey, Ann Dansercoer, Isabel Vandenberghe, Kris Pauwels, Jan Tavernier, Bart N. Lambrecht, Hamida Hammad, Hans De Winter, Rudi Beyaert, Guy Lippens & Savvas N. Savvides
Nature Communications 8, Article number: 14937 (2017)
Recombinant protein therapy
Received: 25 August 2016
Accepted: 15 February 2017
Published online: 03 April 2017
The pro-inflammatory cytokine thymic stromal lymphopoietin (TSLP) is pivotal to the pathophysiology of widespread allergic diseases mediated by type 2 helper T cell (Th2) responses, including asthma and atopic dermatitis. The emergence of human TSLP as a clinical target against asthma calls for maximally harnessing its therapeutic potential via structural and mechanistic considerations. Here we employ an integrative experimental approach focusing on productive and antagonized TSLP complexes and free cytokine. We reveal how cognate receptor TSLPR allosterically activates TSLP to potentiate the recruitment of the shared interleukin 7 receptor α-chain (IL-7Rα) by leveraging the flexibility, conformational heterogeneity and electrostatics of the cytokine. We further show that the monoclonal antibody Tezepelumab partly exploits these principles to neutralize TSLP activity. Finally, we introduce a fusion protein comprising a tandem of the TSLPR and IL-7Rα extracellular domains, which harnesses the mechanistic intricacies of the TSLP-driven receptor complex to manifest high antagonistic potency.
Very interesting! I have had eczema on my face for 10-15 years, maybe longer. It was so bad at one time it use to bleed. I recently have been making great progress treating SIBO and leaky gut.
The healthier I get and therefore my gut gets, the more my eczema has subsided, to the point now where it's 90% gone! It seems clear to me now, that dysbiosis and a leaky gut were causing my eczema. Thanks for posting this very interesting study.
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