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Scientists discover how to 'switch off' autoimmune diseases

Discussion in 'Other Health News and Research' started by melihtas, Sep 3, 2014.

  1. melihtas

    melihtas Senior Member

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    Link to full text of the study: Sequential transcriptional changes dictate safe and effective antigen-specific immunotherapy


    Link to MedicalXpress Article about the study: Scientists discover how to 'switch off' autoimmune diseases

     
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  2. Sasha

    Sasha Fine, thank you

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  3. RL_sparky

    RL_sparky Senior Member

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    http://www.telegraph.co.uk/health/h...switched-off-by-retraining-immune-system.html


    “In allergies the immune system mounts a response to something like pollen or nuts because it wrongly believes they will harm the body.

    “But in autoimmune diseases the immune systems sees little protein fragments in your own tissue as foreign invaders and starts attacking them.

    “What we have found is that by synthesising those proteins in a soluble form we can desensitise the immune system by giving an escalating dose.”

    The team hope that the breakthrough could lead to the development of immunotherapies for individual conditions, based on the protein or antigen that the body is responding too.
     
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  4. Sea

    Sea Senior Member

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  5. alex3619

    alex3619 Senior Member

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    This is a new application of an old principle. Yet I would caution its unclear that this will work with autoinflammatory states.
     
  6. Snow Leopard

    Snow Leopard Hibernating

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    JE has previously commented that these "induced" autoimmune conditions in animal models are not necessarily useful for comparison with natural autoimmune disorders in Humans, so I'm guessing he will consider it mostly speculation at this point.

    This is an interesting idea, but I personally have many reservations about whether it could be useful in a natural autoimmune illness - it first needs to be demonstrated in a real autoimmune illness - merely measuring T-Cell responses is interesting, but not proof that the illness has been suppressed. Besides that, it probably requires very tight control and monitoring of dosages due to the kinetics involved for it to be safe in Humans. Which in turn needs radical new drug delivery methods.
     
    Last edited: Sep 4, 2014
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  7. alex3619

    alex3619 Senior Member

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    Artificial models often mislead. Things work nice in the lab, but fail to work on people. The same goes for animal models. None of these do away with the need for clinical trials.
     
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  8. Kina

    Kina

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    I have merged them. :)
     
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