Within minutes of using the Hydroxy or mixed B vits I get scary symptoms. Right now my left side of body is cold, arm is aching profusely and fingers are tingling. This occurred MINUTES after rubbing in Hydroxy oil with left hand. I thought it was just the Adenosyl in the mixed B vits, as this reaction happened with them. I did not use any for a few days, then tried again today. I have used Hydroxy in MEGA doses before, up to 50mg injected into the subcutaneous fat, with NO SIDE EFFECTS. I feel as though I have rubbed poison into my arm. I will never use these again.