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SAMe Titration

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by SJB944, Feb 23, 2015.

  1. SJB944

    SJB944 Senior Member

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    On Fred's protocol. On small amounts of most basics. Currently taking 8mg MB12 a day, 5mg ADB12, 11.2mg Methylfolate sublingually.

    Introduced 25mg of SAMe - 1/4 of a tablet for one week -- initially some slight energy improvement,now making me feel a flat, slightly anxious or at least vexed, not depressed but a subtle decline in my mental coping ability -- everything overwhelming. Also some gut irritation. Disturbed sleep, waking at 3,30am.

    Anyone else reacted to SAMe and did they titrate up their dose?
     
  2. GhostGum

    GhostGum Senior Member

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    Vic, AU
    Thanks for this post, because I have suddenly had issues the last week, over sleeping and more flat/tired, am pretty sure now it is my over use of Sam-e; was using 1-2 200mg of the Jarrow a day with no titration. I have been on a methylation cycle now for nearly 12 months though, so not sure it matters as much with titration of Sam-e for me?

    Anyway I am going to stop it for a couple of days, then take it easy, maybe 1 200mg tab every second day.

    Always hard to judge what is doing what, maybe we are just having an off week, if it seems to not be working for you stop it and start again later; 25mg seems a pretty small dose.

    Edit: Just to add here, as I understand it, sam-e is suppose to not be so effective without the presence of B12 and other B vitamins, so if you are only in the process of working into methylation supplements you are probably better off leaving sam-e for a while anyway?
     
    Last edited: Feb 24, 2015
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  3. SJB944

    SJB944 Senior Member

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    Thanks @GhostGum do have others vitamin bs in place. Stopped taking the Sam-e for the time being but some gut issues have flared up.

    Wondering if Sam-e can ramp up thirst for folate? If so then the folate deficiency symptoms are different this time than the usual.
     
  4. Sushi

    Sushi Senior Member Albuquerque

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    I reacted at first, then was able to titrate up to 200 mg which is the dose I wanted to take.

    Sushi
     
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  5. SJB944

    SJB944 Senior Member

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    @Sushi Any particular benefit from the SAMe?
     
  6. Sushi

    Sushi Senior Member Albuquerque

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    I take it mainly as part of a methylation protocol but also noticed that it helps my mood.

    Sushi
     
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  7. GhostGum

    GhostGum Senior Member

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    I would be interested to know this as well, it would explain my issues with it, because even though I am on B12 and B's daily I do not take much folate because it does agree with me. Tried adding sam-e again yesterday after a few days off and a bit tired again, so might be a no go.

    Juggling methylation supplements is fun, isn't it :confused:
     
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  8. Oberon

    Oberon Senior Member

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    Sam-E was one of the most noticeable supplements for me in terms of increased physical energy; I was taking 400mg daily and plan on doubling it with another trial later but it is a bit on the expensive side.
     
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