On Fred's protocol. On small amounts of most basics. Currently taking 8mg MB12 a day, 5mg ADB12, 11.2mg Methylfolate sublingually. Introduced 25mg of SAMe - 1/4 of a tablet for one week -- initially some slight energy improvement,now making me feel a flat, slightly anxious or at least vexed, not depressed but a subtle decline in my mental coping ability -- everything overwhelming. Also some gut irritation. Disturbed sleep, waking at 3,30am. Anyone else reacted to SAMe and did they titrate up their dose?