SAM-e.... co-factors to help maintain efficacy?

I've had some luck taking SAM-e... It helps my constant joint pain/stiffness, and my foggy thinking.. However, it seems to fizzle out. Is there a co-factor that I can take to help maintain the efficacy?

BTW - this acetylcholine path seems key for me... (maybe because of the BHMT probs??), so maybe there's a co-factor on the SAM-e pathway that I should take that's BETTER than SAM-e, so I'm open to that, too. I've tried a lot already, but it's a matter of taking the right supps at the right time..

 

Do you take b12? If you dont, it is involved in processes that utilize samE and can have some positive effects in the samE pathway.

 

not sure what the acetylcholine path is but if you are trying to increase acetylcholine levels you could try alpha GPC or citicoline?

see these:

http://www.mindnutrition.com/articles/alpha-gpc-vs-cdp-choline-whats-the-difference

http://forums.phoenixrising.me/index.php?threads/favorite-choline.35930/page-2