I tried sam-e yesterday, just 100 (broke a pill in half). It gave me a supper small peep in my step. But not much at all. However, in the middle of the night I had depression. When I would have one to many beers, I would always wake up in the middle of the night and be depressed, severly. Sam-e cause the same thing last night. Anyone have any suggestions on why this would happen? If it took me really high, I could understand a big crash. But I could hardly tell the difference when on the sam-e.