Professor & patients' paper on the solvable biological challenge of ME/CFS: reader-friendly version
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Salvia Miltiorrhiza

Discussion in 'General Treatment' started by Rand56, Nov 9, 2012.

  1. Rand56

    Rand56 Senior Member

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    Myrtle Beach, SC
    Salvia Miltiorrhiza...AKA.....Red Sage or Danshen. Not to be confused with Salvia Divinorum which some use recreationally as a dissociative and hallucinogen. It has peaked my interest not only as an antioxident and anti-inflammatory, but also it's effects on dopamine and a possible antidepressant...

    http://en.wikipedia.org/wiki/Salvia_miltiorrhiza

    Antioxidant and anti-inflammatory activities of selected Chinese medicinal plants and their relation with antioxidant content....

    http://www.ncbi.nlm.nih.gov/pubmed/23038995

    Antidepressant-like effects of Salvianolic acid B in the mouse forced swim and tail suspension tests.

    http://lib.bioinfo.pl/pmid:22683428


    Is anyone familiar with this herb and/or have used it? Pros? Cons?

    Rand
     
  2. ellenelle

    ellenelle

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    I take dan shen for heart problems, its primary use. It helps noticably with shortness of breath, palpitations, and chest pain. I haven't noticed any particular effects on mood or cognition. Happy to say I haven't had any negative effects, either.

    Ellen
     
  3. RYO

    RYO Senior Member

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    USA
    I can across an article that studied effects of Salvia Miltiorrhiza on Interleukin-12 and interferon gamma. It states Salvia Miltiorrhiza can decrease levels of IL-12 and gamma interferon.

    Interferon gamma is often sited as a cytokine that is elevated in CFS/ME patients. It would be an interesting study to see if this chinese herb can ameliorate CFS/ME symptoms.

    Please note that Salvia Miltiorrhiza has blood thinning effects and should not be take with other prescription blood thinners or antiplatelet agents. Use should also be avoided before any surgery.
     
  4. alex3619

    alex3619 Senior Member

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    Logan, Queensland, Australia
    Gamma interferon is looking like a major problem in ME. Herbs like this might be useful, but many of them are still largely unknown in the community.
     
  5. RYO

    RYO Senior Member

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    USA
    Apparently vitamin D3 can reduce gamma interferon levels. It would an interesting study to evaluate different doses and their effect on gamma interferon levels.

    Also, certain miRNA can regulate gamma interferon levels. There are numerous articles that are very interesting regarding viral and host miRNA function.
     
  6. RYO

    RYO Senior Member

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    USA
    It is also interesting to read about adverse reactions to gamma interferon as a treatment for chronic granulomatous disease.

    Upset stomach, nausea, flu-like symptoms, headache, lightheadedness, mental/mood changes, muscle aches, confusion, depression, irregular heartbeat, joint pains.

    Sound familiar?
     
  7. Sherlock

    Sherlock tart cherry etc. for joints, insomnia

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    Czechosherlockia, USA
    1989
    The regulation of interferon production by aspirin, other inhibitors of the cyclooxygenase pathway and agents influencing calcium channel flux.
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1807783/

     

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