Professor & patients' paper on the solvable biological challenge of ME/CFS: reader-friendly version
Simon McGrath provides a patient-friendly version of a peer-reviewed paper which highlights some of the most promising biomedical research on ME/CFS ...
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SAH to SAM-E Conversation enzymes and cofactors?

Discussion in 'General Treatment' started by DREBS, Jan 2, 2014.

  1. DREBS


    I always do my own research before asking a question that I could have gone and looked up myself but I am simply having a hard time finding the key players in converting S-adenosylhomocysteine hydrolase to SAM-E.

    I'm assuming, just by looking at the cycle and what the numbers saying either something is draining my Sam-e (creatine demand or methyl doners) or it's not properly getting converted to SAH. So my question is around the area of what it needed to convert SAM-E to SAH.

    I've read Phosphatidyl-ethanolamine, PMT (
    phenol O-methyltransferase) and many moreā€¦ I don't know how accurate these are and how you would go about supporting them?

    My Methionine is elevated/ borderline high in amino acid plasma
    My SAM-E is lower 223 REF RANGE 221-256
    However my SAH is high 56.4 REF RANGE 38-49
    As well as my Adenosine 26.9 REF RANGE 16.8-21.4

    Active folate 361 REF RANGE 400-1500
    Oxidized Glutathione barley out of range HIGH
    Reduced glutathione barley out of range LOW

    Per methylation pathway test

    Thanks for you time!
    Last edited: Jan 2, 2014

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