I always do my own research before asking a question that I could have gone and looked up myself but I am simply having a hard time finding the key players in converting S-adenosylhomocysteine hydrolase to SAM-E. I'm assuming, just by looking at the cycle and what the numbers saying either something is draining my Sam-e (creatine demand or methyl doners) or it's not properly getting converted to SAH. So my question is around the area of what it needed to convert SAM-E to SAH. I've read Phosphatidyl-ethanolamine, PMT ( phenol O-methyltransferase) and many more… I don't know how accurate these are and how you would go about supporting them? My Methionine is elevated/ borderline high in amino acid plasma My SAM-E is lower 223 REF RANGE 221-256 However my SAH is high 56.4 REF RANGE 38-49 As well as my Adenosine 26.9 REF RANGE 16.8-21.4 Active folate 361 REF RANGE 400-1500 Oxidized Glutathione barley out of range HIGH Reduced glutathione barley out of range LOW Per methylation pathway test Thanks for you time!