Invest in ME Conference 12: First Class in Every Way
OverTheHills wraps up our series of articles on this year's 12th Invest in ME International Conference (IIMEC12) in London with some reflections on her experience as a patient attending the conference for the first time.
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SAH to SAM-E Conversation enzymes and cofactors?

Discussion in 'General Treatment' started by DREBS, Jan 2, 2014.

  1. DREBS


    I always do my own research before asking a question that I could have gone and looked up myself but I am simply having a hard time finding the key players in converting S-adenosylhomocysteine hydrolase to SAM-E.

    I'm assuming, just by looking at the cycle and what the numbers saying either something is draining my Sam-e (creatine demand or methyl doners) or it's not properly getting converted to SAH. So my question is around the area of what it needed to convert SAM-E to SAH.

    I've read Phosphatidyl-ethanolamine, PMT (
    phenol O-methyltransferase) and many moreā€¦ I don't know how accurate these are and how you would go about supporting them?

    My Methionine is elevated/ borderline high in amino acid plasma
    My SAM-E is lower 223 REF RANGE 221-256
    However my SAH is high 56.4 REF RANGE 38-49
    As well as my Adenosine 26.9 REF RANGE 16.8-21.4

    Active folate 361 REF RANGE 400-1500
    Oxidized Glutathione barley out of range HIGH
    Reduced glutathione barley out of range LOW

    Per methylation pathway test

    Thanks for you time!
    Last edited: Jan 2, 2014

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