Hi all. New here and glad to have found this place Short run down: I've been treating macrocytic anemia since July. Numbers are improving, but have neurological symptoms. I decided to get 23andme testing since having a long wait to get neuro appointment and internet sleuthing. Now waiting on MRI scheduling. Neuro just said to keep taking b12 and that he did not know anything about methylation or genetic variances related to it. Last blood work showed off the charts high b12 serum (1923) and also high serum folic acid > 19.9 but still macrocytic. The results of my SNP's for methylation are as follows: MAO A R297R +- MTHFR C667T ++ MTRR A66G ++ MTRR A664A +- BHMT-02 ++ BHMT-04 ++ BHMT-08 ++ CBS A360A ++ Any ideas for a better approach to handling supplementation? I feel as if my body and muscles are always "electrically charged", seem to get system overload from too much going on, lack of focus, and also big fatigue. The strange thing is, the fatigue is quite variable, sometimes awful, and other days I manage really well. As an aside, I've been Paleo (meats, veggies and smae amounts of fruits and nuts), sugar and caffeine free since September. Thanks in advance for any thoughts shared.