I took so long to reply sorry - I am also confused about the Nancy Klimas and others suggesting the breaks - the first time when I came right in 16 months I took it everyday - it was early days ie 5 years agao. Now I take 6 perday but everynow and then have a break in the weekends. My doc says she doesn't know why the break but as I was usccessful? last time to take it everyday. Also on another thread have found a cheaper source from Goldpharm. Look it up - I'm thinking I will try to find out more about it as it is half the cost of getting it from my pharmacist.