Does anyone know if there are any studies on using Russian immunomodulators for chronic fatigue syndrome? Russian immunomodulators include: arbidol, which is an immunostimulant and interferon inducer, with some efficacy against coxsackievirus B3 and B5. Arbidol has a very good safety profile. Then there is tilorone (Amixin), an interferon inducer which stimulates the formation of alpha, beta and gamma interferons. And cycloferon which is antiviral, immunomodulating and anti-inflammatory. These drugs can be bought at: www.pharmacy1010.ru The virtue of these drugs is that they are all relatively cheap. I tried 1 arbidol 100 mg tablet daily for a week as an initial experiment, without any noticeable improvements - but you might have to take these drugs longer than that, I guess. No doubt these immunomodulators are not going to match the potency of having one month of daily intravenous interferon alpha / delta combination therapy (as used by Dr John Chia, which put many patients with enterovirus CFS into remission for one or two years). But with typical intravenous interferon therapy costing US$5000 per month, and with there being unpleasant side effects with intravenous interferon (like constant depression during the treatment), some of these mild and safe interferon inducers may be a cheaper alternative, albeit probably very much weaker one. There are many more Russian / Eastern immunomodulators. Here is a comprehensive list: Amyxin, Amizon, Anandin, Arbidol, Blasten, Cycloferon, Galavit, Groprinosinc, Hepon, Immunoxel, Dzhcrelo, Kagoccl, Larifan, Ligfol, I.ikopid, Mebavin, MIG1-K-LP, V-5-Immunitor, SCV-07, Milife, Neovir, Poludan, Ragocin, Ridostin, Thymogen, Savratz. These are not that well known in the West. More info here: Synthetic and natural immunomodulators acting as interferon inducers Immunomodulators In Russia The Home Immunomodulators of the Last[est] Generation Natural IFN alpha inducer supplements include: Interferon Alpha Inducers: Garlic † † Reishi (Ganoderma lucidum) † Astragalus Bupleurum kaoi † Baicalin (from skullcap) † PABA † The last three (Bupleurum kaoi, baicalin and PABA) also stimulate interferon beta.