Hello all! Some people consider that there is a factor that dis-balance the immune system and then creates a defective immune system that could cause the CFS. I would have a work hypothesis - what if the immune deficiency is the result of a high, very intensive period of overstress? I would mention 3 categories of stress (and just give a couple of examples) 1) psychological stress (like feeling prisoner and being unable to break a closing loop in your life, not being able to adapt to a new environment, not being able to change something in your life because of a dependence on an external factor, feeling marginalized and useless in community, etc) 2) intellectual stress (like doing a very stressful job - like a programmer that has to fix bugs under time pressure) 3) physical stress (like doing too much exercises in Gym ) I experienced very high stress in all 3 categories a few years before my CFS started and just asking myself if this overstress was the factor that triggered my disease. Some of us want to push our limits far and far... But we do not know where exactly is our final limit, beyond that limit is only a crash - our body just collapses. Is like you are stretching a string until that string breaks. I felt at some point in time - that something was broken in my body (and is not a metaphor), and then the disease started a few months later and the recovering of the body by itself was not anymore possible. In 2007-2010 I had very high stress of types 1) and 2). In 2010, after 3 years of very high pressure I got viral infection (most probably H1N1). In late 2011 I experienced stress of type 3) for a few months. In beginning of 2012 my disease started to manifest, i was not able to do too much. What do you think? Is overstress a possible trigger of the immune deficiency?