Hi all I have CFS and lyme and a host of other related issues (adrenal, thyroid and sinus problems). My doctor started giving me shots of rocephin. I have had two so far. After my first shot I felt horrible for the first day or two after but then I felt almost totally well. I believe a lot of my issues are in my brain, and maybe my brain might be swollen(?) I now even think that my sinus issues might be tied to the brian swelling. At any rate, the rocephin and the flagyl that I am already taking seem to be really helping. Does anyone else have experience with this? I am certainly not expecting this improvement to last, but it's nice while I have it. Is there anything else I can do about brain inflammation?