The 12th Invest in ME Conference, Part 1
OverTheHills presents the first article in a series of three about the recent 12th Invest In ME international Conference (IIMEC12) in London.
Discuss the article on the Forums.

Rituxumab and its relation to CD19 Cells Question

Discussion in 'Rituximab: News and Research' started by Justin30, Sep 7, 2016.

  1. Justin30

    Justin30 Senior Member

    Messages:
    1,065
    Likes:
    1,272
    Hi,

    My question is in relation to CD 19 cells.

    Does anyone know or have data that suggests a response to Rituximab if CD 19 are low or high?

    Info would be much appreciated.

    Thanks
     
  2. Gingergrrl

    Gingergrrl Senior Member

    Messages:
    8,911
    Likes:
    21,921
    USA
    Is CD19 an autoantibody and does it relate to lymphoma or am I totally confused? I apologize I also do not know the answer to your question!
     
  3. Justin30

    Justin30 Senior Member

    Messages:
    1,065
    Likes:
    1,272
    Now it is just an B cell level that is measured maybe @Jonathan Edwards could shed some light on it as I am a bit confused about the levels and their meanings as well.
     
    Gingergrrl likes this.
  4. Jonathan Edwards

    Jonathan Edwards Senior Member

    Messages:
    5,019
    Likes:
    29,076
    B cell levels vary widely in normal blood. They probably do not mean much because B cells only pass through blood very transiently. They do not do anything there. It is a bit like trying to gauge how many people live in a town by looking out of the window to see how many people are on the street. As far as I know counts tell us nothing about autoimmune disease. (They are very high in B cell leukaemia but that is a completely different issue.) I have not seen any evidence that high or low counts affect response to rituximab in any autoimmune disease.

    On a wider front counts of lymphocyte populations in individual people are not very likely to tell us much in ME/CFS. There may be statistical trends across groups of ME patients of interest but one off measurements for single individuals probably mean nothing.
     
    Marky90, cfs6691 and MEMum like this.

See more popular forum discussions.

Share This Page