Some people with ME do spontaneously improve and even go into remission. For example, I have CCC/ICC acute viral onset ME and after years bedbound, I went into some years of partial remission during which I was able to work full-time and have a pretty normal life, until I eventually relapsed back to being bedbound/housebound. Given that, does the outlook for the use of Rituximab in PWME look more promising than for people with RA? Do people with RA every have spontaneous substantial improvement and/or years of substantial remission? I'm wondering if it's possible to "reset" at least some PWME by using Rituximab without the necessity for the treatment being long-term in all cases.