I get what many say about immune system defects. No doubts in my mind that unusal immune responses are common in both ME and CFS. But I just dont buy into the idea that sufferers are genetically predisposed to have those sort of problems. I think the problems with the immune system are acquired and are caused in most cases (of CFS) by an adverse drug reaction and, in some cases, adverse supplement reaction. The idea that because something can be bought from a health food store it must be "healthy" is cobblers. Supplement manufacturers in the UK get away with far to much when it comes to not having to prove the safety and effectiveness of their products.