The End ME/CFS Project: History Taking Root
The history books record that in the nineteenth century Louis Pasteur formulated a “germ theory” of microbes as the causative agents of disease, and thus revolutionized medicine. His findings, along with his contemporary, John Snow (who linked cholera to infected water supply),...
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Rituximab maintenance therapy: a step forward in follicular lymphoma

Discussion in 'Rituximab: News and Research' started by Andrew, Feb 4, 2012.

  1. Andrew

    Andrew Senior Member

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  2. Snow Leopard

    Snow Leopard Senior Member

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    Thanks.

    Which study has followed this up for the longest period of time? This one appears to be about 2 years (and n=151).
     
  3. Andrew

    Andrew Senior Member

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    I don't know what the follow up was. I thought I'd get this posted and maybe check later.
     
  4. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    I wonder if maintenance can be maintain with antivirals after ritux treatment. AV's have a saver side effect profile from what we know so far??

    cheers!!!
     
  5. Andrew

    Andrew Senior Member

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    I guess it depends on how cfs works. If killing b cells is the trick, then I don't see what the AV would do.
     
  6. anciendaze

    anciendaze Senior Member

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    This depends on why killing CD20 B-cells works. These are cells which hold antigens as memory cells for the immune system. In the case of viruses the entire virus may be in there. Holding the virus in check while other B-cells reconstitute normal immune function might be useful.
     
  7. currer

    currer Senior Member

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    It is not known how this therapy works for other diseases - so to expect answers in the case of ME is a bit much. Many drugs are used therapeutically without knowing how they work exactly.

    They could be killing off the retrovirally infected cells and thus reducing the tissue load. Who knows?

    We need more research.
     
  8. Snow Leopard

    Snow Leopard Senior Member

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    From an idealistic point of view, if the phase 3 trial for Rituximab is successful, it is beneficial not necessarily just as a (non-specific) treatment, but also a clue for further research and development of more specific drugs. Responding to Rituximab creates a novel subgroup for study. (and blood can be banked beforehand for later study).

    Of course as Currer said, expecting answers in the short term is a bit much.
     

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