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Rituximab For RA Shows Small Increase In Hepatitis B Reactivation

Discussion in 'Rituximab: News and Research' started by Never Give Up, May 5, 2016.

  1. Never Give Up

    Never Give Up Collecting improvements, until there's a cure.

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    This adds some support to the idea that if ME is caused by viruses, and Rituximab suppresses immune response to those viruses, then we might see a worsening of the condition in the long run with Rituximab use.

    http://www.jrheum.org/content/43/5/869.abstract
     
    merylg and halcyon like this.
  2. BurnA

    BurnA Senior Member

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    I had a quick look and I am not sure how you formed your speculation.

    This is talking about reactivation of HBV. And it states

    Maybe i missed something ?
     
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  3. Gingergrrl

    Gingergrrl Senior Member

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    But this would only be if someone had prior Hep B infection, not that RTX causes it?
     
  4. Kati

    Kati Patient in training

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    It is well known that there is a risk of HepB reactivation for those who have the virus (not the vaccine) and who are started on Rituximab. It is a relative contraindication and the physicians have to thread very carefully.
     
    merylg likes this.
  5. Gingergrrl

    Gingergrrl Senior Member

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    But if someone never had HepB and tests negative for it, then they are okay? No worries, Kati, if you do not know. I assume physicians know which tests to order before someone has RTX for any condition (or I'd hope!)
     
  6. Kati

    Kati Patient in training

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    Yes, you're ok if you never had Hep B. It is difficult to get unless you are living an at-risk lifestyle or it was transmitted through birth.
     
    Last edited: May 5, 2016
  7. Gingergrrl

    Gingergrrl Senior Member

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    Thanks and that's what I thought. Great to hear confirmation though and I do not have HepB.
     

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