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Rituximab For RA Shows Small Increase In Hepatitis B Reactivation

Messages
2,087
This adds some support to the idea that if ME is caused by viruses, and Rituximab suppresses immune response to those viruses, then we might see a worsening of the condition in the long run with Rituximab use.

http://www.jrheum.org/content/43/5/869.abstract

I had a quick look and I am not sure how you formed your speculation.

This is talking about reactivation of HBV. And it states

The administration of RTX + DMARD in patients with RA with resolved HBV infection leads to a negligible risk of HBV reactivation,

Maybe i missed something ?
 

Gingergrrl

Senior Member
Messages
16,171
But this would only be if someone had prior Hep B infection, not that RTX causes it?
 

Kati

Patient in training
Messages
5,497
It is well known that there is a risk of HepB reactivation for those who have the virus (not the vaccine) and who are started on Rituximab. It is a relative contraindication and the physicians have to thread very carefully.
 

Gingergrrl

Senior Member
Messages
16,171
It is well known that there is a risk of HepB reactivation for those who have the virus (not the vaccine) and who are started on Rituximab. It is a relative contraindication and the physicians have to thread very carefully.

But if someone never had HepB and tests negative for it, then they are okay? No worries, Kati, if you do not know. I assume physicians know which tests to order before someone has RTX for any condition (or I'd hope!)
 

Kati

Patient in training
Messages
5,497
But if someone never had HepB and tests negative for it, then they are okay? No worries, Kati, if you do not know. I assume physicians know which tests to order before someone has RTX for any condition (or I'd hope!)
Yes, you're ok if you never had Hep B. It is difficult to get unless you are living an at-risk lifestyle or it was transmitted through birth.
 
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Gingergrrl

Senior Member
Messages
16,171
Yes, you're ok if you never had Hep B. It is difficult to get unless you are living an at-risk lifestyle.

Thanks and that's what I thought. Great to hear confirmation though and I do not have HepB.