The 12th Invest in ME Conference, Part 1
OverTheHills presents the first article in a series of three about the recent 12th Invest In ME international Conference (IIMEC12) in London.
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Rituximab and mast cell disorders w/me

Discussion in 'Mast Cell Disorders/Mastocytosis' started by sillysocks84, Sep 29, 2015.

  1. sillysocks84

    sillysocks84 Senior Member

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    I am not sure if anyone knows this yet, but I know many of us have problems developing allergies to pretty much anything. Has anyone heard if RTX has helped mast cell problems within the clinical trials? This is one of my worst symptoms. I'd be fine if only this part would go away. Well some days I feel that way anyways... Feel free to tag someone too if you think they may know or have a better understanding of RTX in relation to mast cells in our disease.
     
  2. Scarecrow

    Scarecrow Annie Gsampel

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    Scotland
    Sorry I can't give you a detailed or definitive answer but in the study here, one of the antibodies, that was elevated in patients and that fell with rituximab treatment, was to the β2 adrenergic receptor, which is involved in inhibiting histamine release from mast cells.

    https://en.wikipedia.org/wiki/Beta-2_adrenergic_receptor
     
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  3. sillysocks84

    sillysocks84 Senior Member

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    That wiki is a wealth of information, gives me a big clue that my receptor isn't functioning great just by going down the list. Thank you for sharing!
     
    Scarecrow likes this.

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