The Real ME: A Stock Photography Resource for the Media
We’ve all seen them in the news stories about ME/CFS: the guy in a suit at the office, yawning; the beautiful woman sitting at her desk with her immaculate make-up and elegantly coiffed hair, hand to her head and looking slightly pained.
Discuss the article on the Forums.

Rituximab also depletes T cells

Discussion in 'Rituximab: News and Research' started by AdamS, Sep 10, 2017.

  1. AdamS

    AdamS Senior Member

    Messages:
    262
    Likes:
    765
    In the OMF Syposium video, Prof Mark Davis presented some incredibly interesting stuff regarding T cells. In particular that there is probably a triggering antigen in ME/CFS and that CD8 clonal expansion, similar to that seen in MS & cancer is present in ME/CFS patients.

    I always thought Rituximab was designed to deplete B cells alone, but after a quick Google I found this:

    Source: https://www.ncbi.nlm.nih.gov/m/pubmed/23918413/

    I'm sure some of you may have been aware of this for a while but I found it interesting/exciting given Mark Davis's findings!
     
    Aroa, Hutan, Woolie and 3 others like this.
  2. AdamS

    AdamS Senior Member

    Messages:
    262
    Likes:
    765
    Additionally, it would appear that T-cell activation and proliferation can be modulated by using calcineurin inhibitors (cyclosporine, tacrolimus), mTOR inhibitors (sirolimus), and antiproliferative agents (methotrexate, cyclophosphamide, or mycophenolate). Perhaps this is why we have some anecdotal reports of Sirolimus helping a bit and it could point towards Cyclo having benefit for some patients if T cells are involved/responsible in some way! (Pretty sure Fluge & Mella have a CycloME trial in progress atm, correct me if i'm wrong).

    Source: http://www.bloodjournal.org/content/117/23/6061?sso-checked=true
     
    Aroa likes this.
  3. Gingergrrl

    Gingergrrl Senior Member

    Messages:
    9,543
    Likes:
    24,660
    USA
    This is interesting and I have done the Lymphocyte subset panel twice (one month apart) after having the initial two Rituximab infusions in mid July and early Aug. I do not have the 2nd test results back yet (hopefully tomorrow) but I believe in the first test that my T cells were normal and unaffected. My B cells were at zero after the first infusion which is the goal of Ritux. Now I intend to look at T cell levels for both sets of tests and am very curious!
     
    Aroa, Hutan, ebethc and 2 others like this.
  4. AdamS

    AdamS Senior Member

    Messages:
    262
    Likes:
    765
    Definitely sounds worthwhile, yes it will be interesting to see if T cell levels correpond with clinical response in Ritux or other treatments for ME/CFS.

    Also, I hope you're doing okay with your treatment, I don't post as much here anymore but have been following your story!
     
    Gingergrrl likes this.
  5. Gingergrrl

    Gingergrrl Senior Member

    Messages:
    9,543
    Likes:
    24,660
    USA
    Addendum: I am wrong and some of the other numbers were flagged as low in addition to the B cells but I am not sure what they all mean or how to interpret them. If I posted the numbers, do you know what they mean @AdamS?

    Edit: We cross posted at exact same moment and thank you for the good wishes re: following my story!
     
  6. AdamS

    AdamS Senior Member

    Messages:
    262
    Likes:
    765
    I probably wouldn't unfortunately @Gingergrrl i'm sure others would though :)
     
    Gingergrrl likes this.
  7. Gingergrrl

    Gingergrrl Senior Member

    Messages:
    9,543
    Likes:
    24,660
    USA
    No worries! I looked more carefully at the first Lymphocyte Subset Panel that I did after the first infusion of Ritux (but prior to the second one). I did the second LSP more recently but don't have the results back yet.

    In the first one, there are a total of 12 items and five were flagged as low but three relate to B-cells so I believe this is '"normal" and the goal of Ritux. I am not sure about the additional two things that were flagged and suspect they relate to T cells. My doctor was not concerned at all at the time so I did not question it any further since I didn't really know what I was looking at (beyond the Absolute CD19 and the %CD19 meaning the B cells being at zero).
     
  8. BurnA

    BurnA Senior Member

    Messages:
    2,086
    Likes:
    9,863
    Discussed here
    http://forums.phoenixrising.me/inde...which-rtx-might-be-working.37669/#post-599316
     
    AdamS, Aroa and Gingergrrl like this.

See more popular forum discussions.

Share This Page