Its encouraging that a drug used for cancer and other "autoimmune" diseases has a positive effect on our illness. However, I'd be very careful assuming that this means out illness is "autoimmune". Thats a very ill defined and slippery slope to go down. It seams that many times, scientists who can't figure out an obvious cause for an illness that involves immune activation will deem it "autoimmune" and then call it a day and stop looking for the actual cause. That would be a huge blow to ME/CFS research as there is much evidence that our illness is actually an infectious disease - cluster outbreaks, family members getting sick at the same time, people becoming ill following blood transfusion, etc... In other words, the epidemiological history of ME/CFS does not lend itself to an autoimmune pattern. Not to mention that Rituximab basically obliterates the B cells, which while reducing symptoms, might not be such a good thing in the long run. I'm sure some of us would feel better on prednisone as well because it knocks back the immune response. But you better be sure the immune system isn't actually doing something useful (like battling a chronic infection) before you try that.