Just wanted to give an update. About 6 and 1/2 months after the fourth round of Rituxan I contacted my doctor and told him I was seeing some signs that the RTX was wearing off. He said I had to do some B-Cell tests in order to know if I am due for a maintenance dose, so I drove the 8-9 hour round trip just to do the test. He contacted me and said no it was too soon. Now jump ahead 2 months and I write him again and tell him I am really going down hill. He requests I come in again and have the B-Cell test which I do. He calls me and says yes it is time, I will need two rounds instead of one. I am going this Wed for round one. I am in HORRID pain again in all joints, massive headaches, profound fatigue all the things we all complain about. The only thing that has stayed strong is my ability to think clearly. Which is great as this has always been so debilitating. It is very very hard to go back down hill after having several months of feeling so great, I am bummed this doesn't last longer. My joint pain is unbearable, worse than I ever remember. I just cry myself to sleep at night. You know if it was just in one or two joints or maybe some neck pain it would be fine but pain in every single joint, hip, and spine is so overwhelming and on top of that the severe burning in my feet is back, so I know the RTX for sure helped that. I am really sick with a cold and a little fearful about doing the RTX but I was suppose to do it two weeks ago and I put it off because I had a bad fungal infection in my central line. ( there was a spot in my lung either fungus or pneumonia) I can't stand the joint pain and being bed ridden again so I am going for it. I hope you all are doing ok and sorry I haven't visited more but I have been so sick I couldn't do any computer work.