I'll get to the remaining points regarding Anthony Holland's work a little later. But for now... I haven't seen some of those claims, but I would have the exact same questions you do. Even Rife himself didn't make all these claims. At this point, they are just claims and nothing else. No one in this thread has stated otherwise. That's true - even Anthony Holland and his collaborating scientists see human trials as being many years off. Obviously, you have to examine the results before you make any claims about them, and I did. First of all, since I searched for "anecdotal evidence", I got relevant results. For example, from the first hit: This is exactly how I was using "anecdotal evidence" in my previous post. Note that even this short quote, anecdotal evidence is clearly regarded as a type of valid knowledge - it's valid not necessarily in the sense that its implications are correct (they may or nay not be), but because it tells us what has been observed so far. It's just the first step, as I have pointed out, but it's knowledge. I would urge you (and everyone else here to watch the TEDx talk by Anthony Holland from beginning to end. It's 17 minutes, and will correct a lot of misconceptions about Holland's work that have been published in this thread. Yes, I am aware of this. A little research into Lyme disease would have shown that Doug's case is not unusual at all. A simple family hike through a tick-infested area would be all that would be needed for the whole family to come down with Lyme. Alternately, simply living in a Lyme-infested region could explain this. There are many scenario's in which Doug's family could have gotten Lyme while he didn't, until a slightly later encounter with an infected tick.