Vinod3X3 Thank you for so eloquently expressing the wisdom of going slowly with the methylation protocol. I totally agree. The more fragile one's condition, the more slowly one should go. I am continuing with my very low doses of methylfolate and mB12. For a month or two, I tried to add on various other vitamins, also at extremely low doses, but I've stopped those. I intend to restart them, one at a time, and wait 2 weeks in between the addition of anything new. I continue to have increased stamina/energy.