Hey guys, Just found out i have a positive ANA with heavy matrilineal rheumatic autoimmune disease history (mom and grandma). I haven't been officially diagnosed with anything yet. I also have MTHFR, CBS and COMT snps and possible Hg poisoning and maybe a chronic infection. I did great on MB12, Mfolate et all for a one day, then was hit with brainfog, fasiculations and parasthesia and foggyness. I thought this was a detox...was this possible an autoimmune flareup instead? should I stay away from methylation cycle supps? Frustrating cause obviously I need them... I felt much better.. Looks like I'm stuck. Any advice??? Getting a urine AA test soon, hopefully that will shed light on things.