This small study provides some good evidence for a mechanism of ribose. I know it's been extremely helpful for me. It might be a link between methylation block and mitochondrial dysfunctions The role of ribose on oxidative stress during hypoxic exercise: a pilot study Seifert, J. et al JOURNAL OF MEDICINAL FOOD J Med Food 12 (3) 2009, 690693 ABSTRACT Oxygen free radicals are produced during stress, are unstable, and potentially interact with other cellular components or molecules. This reactivity can influence cellular function, including a prolongation in tissue recovery following exercise. We tested the effect of ribose (d-ribose), a pentose carbohydrate, in a double-blinded, crossover study on markers of free radical production during hypoxic exercise. Seven healthy volunteers cycled at their lactate threshold for 25 minutes while inhaling 16% O2 with a subsequent 60-minute resting period at room air. Subjects ingested either placebo or 7 g of ribose in 250mL of water before and after the exercise session. Urinary malondialdehyde (MDA) and plasma reduced glutathione levels increased significantly during placebo ingestion (0.2 +/- 0.03 nM=mg and 0.26 +/- 0.29 mM, respectively) but were lower with ribose supplementation (0.04 +/- 0.03 nM=mg and 0.3 +/- 0.29 mM, respectively; P < .05). Uric acid levels were similar between groups (ribose vs. placebo, 4.5 +/- 0.06mg=dL vs. 4.67 +/- 0.06mg=dL). Ribose demonstrated a beneficial trend in lower MDA and reduced glutathione levels during hypoxic stress.