Invest in ME Conference 12: First Class in Every Way
OverTheHills wraps up our series of articles on this year's 12th Invest in ME International Conference (IIMEC12) in London with some reflections on her experience as a patient attending the conference for the first time.
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Ribose and oxidative stress during hypoxic exercise

Discussion in 'General Treatment' started by kaffiend, Jun 29, 2011.

  1. kaffiend

    kaffiend Senior Member

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    California
    This small study provides some good evidence for a mechanism of ribose. I know it's been extremely helpful for me. It might be a link between methylation block and mitochondrial dysfunctions

    The role of ribose on oxidative stress during hypoxic exercise: a pilot study
    Seifert, J. et al
    JOURNAL OF MEDICINAL FOOD
    J Med Food 12 (3) 2009, 690693

    ABSTRACT Oxygen free radicals are produced during stress, are unstable, and potentially interact with other cellular components or molecules. This reactivity can influence cellular function, including a prolongation in tissue recovery following exercise. We tested the effect of ribose (d-ribose), a pentose carbohydrate, in a double-blinded, crossover study on markers of free radical production during hypoxic exercise. Seven healthy volunteers cycled at their lactate threshold for 25 minutes while inhaling 16% O2 with a subsequent 60-minute resting period at room air. Subjects ingested either placebo or 7 g of ribose in 250mL of water before and after the exercise session. Urinary malondialdehyde (MDA) and plasma reduced glutathione levels increased significantly during placebo ingestion (0.2 +/- 0.03 nM=mg and 0.26 +/- 0.29 mM, respectively) but were lower with ribose supplementation (0.04 +/- 0.03 nM=mg and 0.3 +/- 0.29 mM, respectively; P < .05). Uric acid levels were similar between groups (ribose vs. placebo, 4.5 +/- 0.06mg=dL vs. 4.67 +/- 0.06mg=dL). Ribose demonstrated a beneficial trend in lower MDA and reduced glutathione levels during hypoxic stress.
     
  2. kaffiend

    kaffiend Senior Member

    Messages:
    167
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    132
    California
    It would be interesting to know if ribose actually goes into the recycling of ATP or limits the glycation of glucose
     
  3. Sallysblooms

    Sallysblooms P.O.T.S. now SO MUCH BETTER!

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    Southern USA
    I saw a difference when I started D ribose.
     
  4. mellster

    mellster Marco

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    San Francisco
    Same here - definitely gives energy and ups exercise tolerance.
     

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