Hi jimmy86, I started taking higher dose s-acetyl glutathione 2 weeks ago and it's been a big help. Last week, I even went to a 5 day Vajrayana retreat, commuting 40 minutes each way and not getting much sleep. At the end of the retreat, I ran out of s-acetyl glutathione and crashed hard. After 2 days, I dragged myself over to a friend's and got some more SAG. To my amazement, I came out of the crash in about 15 minutes and was able to go directly to a family birthday party. Currently, I'm taking 1200 - 2700 mg. of SAG, or 1.5 - 2.7 grams per day. Usually I take 1500 grams in the morning, and take more if I have an infection, take in something toxic, exercise, or have a lot of stress. I also take a lot of minerals to support methylation and glutathione production. To save money, I decided to try buying directly from the manufacturer that makes most of the brand name SAG that you see on the market. It's a lot cheaper that way, and the powder is 99.3% pure. My expectation is that taking higher doses of SAG will work well for most people, but not for all. Two of my friends can only tolerate small amounts, and both of them have severe gut problems. According to Chris Shade, inflammation in the small intestine causes phase II detox to get backed up in the liver, which is where glutathione does its thing. So it may be important to clear the gut of mercury, parasites, enteroviruses or SIBOs first so that bile can drain toxins out of the liver.