Join the National PR Campaign for ME: Power to the Patient (P2tP)
Have you had enough of all the neglect and abuse of ME/CFS patients? Gabby Klein says now is the time for a National PR Campaign for ME/CFS to impress a change. Join the Patient Revolution to restore power to ME patients ...
Discuss the article on the Forums.

Review of infection and autoimmune syndromes

Discussion in 'Other Health News and Research' started by kaffiend, Sep 14, 2011.

  1. kaffiend

    kaffiend Senior Member

    Messages:
    166
    Likes:
    123
    California
    This is an interesting perspective from Nature Reviews Rheumatology, July 2011. The paper documents several cases of autoimmunity linked to reactivation of viruses.


    Autoimmune-like syndromes during TNF blockade: does infection have a role?
    Joerg C. Prinz

    Nature Reviews Rheumatology 7, 429-434 (July 2011) | doi:10.1038/nrrheum.2011.35

    Abstract
    Tumor necrosis factor (TNF) antagonists are effective treatments for immune-mediated inflammatory disorders. The most dreaded adverse events associated with these agents are severe infections. Occasionally, patients develop autoimmune-like syndromes (AILS), which include episodes of lupus-like syndrome, multiple-sclerosis-like demyelination and inflammatory neuropathies. The underlying pathologic mechanisms of these syndromes remain, however, matters of debate. Evidence indicates that the onset of systemic lupus erythematosus, inflammatory nervous system demyelination or peripheral neuropathies in the general population may have infectious etiologies. This article discusses whether infectious agents might also have a role in the development of AILS during anti-TNF therapy. TNF antagonists might facilitate the dissemination of dormant or newly acquired viral or bacterial infections, which either directly promote symptoms that mimic autoimmune diseases or break immunological tolerance and induce autoimmunity in predisposed individuals. The occurrence of AILS during TNF blockade should, therefore, lead to reliable infection screening strategies to identify infection-induced autoimmunity and autoimmune mimics.
     

See more popular forum discussions.

Share This Page