1. Patients launch a $1.27 million crowdfunding campaign for ME/CFS gut microbiome study.
    Check out the website, Facebook and Twitter. Join in donate and spread the word!
August 8th - What is the one thing about suffering with severe ME that the world needs to know?
Andrew Gladman brings our coverage of the Understanding & Remembrance Day for Severe ME, airing the voice of patients ...
Discuss the article on the Forums.

(Review) Chronic fatigue syndrome, the immune system and viral infection.

Discussion in 'Latest ME/CFS Research' started by Esther12, Sep 13, 2011.

  1. Esther12

    Esther12 Senior Member

    Messages:
    5,133
    Likes:
    5,002
    I didn't read this properly, as I'm not really up on the terminology/science, but thought it may be of interest to others. (ps: I think Bansal is a bit psychosocial.)


    Full title: Chronic fatigue syndrome, the immune system and viral infection.

    Authors: Bansal AS, Bradley AS, Bishop KN, Kiani S, Ford B.

    Source: Dept. of Immunology, Epsom and St. Helier University Hospitals NHS Trust, Carshalton, Surrey, SM5 1AA and Chronic Illness Research Team, Stratford Campus, University of East London, London E15 4LZ, UK.

    Publication: Brain Behav Immun.
    Publication date: 2011 Jul 2. [Epub ahead of print]

    Abstract
    The chronic fatigue syndrome (CFS), as defined by recent criteria, is a heterogeneous disorder with a common set of symptoms that often either follows a viral infection or a period of stress. Despite many years of intense investigation there is little consensus on the presence, nature and degree of immune dysfunction in this condition. However, slightly increased parameters of inflammation and pro-inflammatory cytokines such as interleukin (IL) 1, IL6 and tumour necrosis factor (TNF) ? are likely present. Additionally, impaired natural killer cell function appears evident.

    Alterations in T cell numbers have been described by some and not others. While the prevalence of positive serology for the common herpes viruses appears no different from healthy controls, there is some evidence of viral persistence and inadequate containment of viral replication. The ability of certain herpes viruses to impair the development of T cell memory may explain this viral persistence and the continuation of symptoms. New therapies based on this understanding are more likely to produce benefit than current methods.

    Full text here: https://docs.google.com/viewer?a=v&...DUwYjRjMTFiNTVm&hl=en_US&pli=1&forumid=331851
  2. Esther12

    Esther12 Senior Member

    Messages:
    5,133
    Likes:
    5,002
    That's what I thought. It seemed to make some sensible suggestions too. I don't understand the science well enough to really comment on it, but I was surprised to see something like this come from mainstream UK CFS research. That it did so could mean it will be harder to ignore too.

    Thanks for your thoughts.
  3. alex3619

    alex3619 Senior Member

    Messages:
    6,800
    Likes:
    10,310
    Logan, Queensland, Australia
  4. Boule de feu

    Boule de feu Senior Member

    Messages:
    1,115
    Likes:
    57
    Ottawa, Canada
    This is so sad, Alex.
    I'm lucky i am Canadian.
  5. Mark

    Mark Acting CEO

    Messages:
    4,501
    Likes:
    1,923
    Sofa, UK
    Interesting quote from that article:

    Genetic factors affecting the likelihood of developing CNS pathology, and ME/CFS in particular, seem likely to me to be an increasingly important area of research. The 2:1 F:M ratio has always seemed suggestive to me, and this quote seems to suggest that this ratio represents proportionate genetic disposition to develop CNS pathology after certain viral illnesses. The quote really strikes me as a crucial clue to the big picture...worthy of some consideration...the 2:1 ratio, it seems, applies to CNS pathology in general, of which 1/3 includes ME/CFS...suggesting that the 2:1 represents genetic vulnerability to CNS pathology. I wonder who is the doctor referred to here?
  6. Morgaine

    Morgaine

    Messages:
    37
    Likes:
    12
    According to the ME Association Facebook page, the son of the editor of Public Service has ME, hence the sympathetic stance story wise.
  7. Enid

    Enid Senior Member

    Messages:
    3,309
    Likes:
    840
    UK
    Seems to be a sad truth amongst the majority that either it has to be experienced directly or en famille so to speak.

See more popular forum discussions.

Share This Page