I've never actually talked about sex hormones with my LLMD but she's on board because she writes the prescriptions! I would be hesitant to start progesterone cream without estrogen as well as you could easily start to become progesterone dominant. Most people are more familiar with estrogen dominance but the reverse is also possible and equally undesirable. As far as UK options, I have a friend who gets a product called Hormonin on the NHS which is very similar to Tri-Est here in the USA. Other options would be to order from overseas (Inhousepharmacy.biz is one idea). They stock everything from Premarin to Progynova and estrogen patches as well. It often takes a bit of trial and error to figure out the best regimen but with your levels, quite honestly, I would think anything would be better than nothing! Alternatively, there is a low dose estrogen cream called Bi-Estro available OTC from iHerb.com. You would have to use a ton of cream to get a reasonable dose, but it is certainly a workable option. Here is a website that discusses HRT options and there is a section devoted to UK products (it's equally valid for women in perimenopause as well as early menopause so don't be offended by the title!): http://www.earlymenopause.com/ukhrt.htm Estrogen is usually replaced for either the entire cycle or can be paused during menstruation. I take it every day. Progesterone is pretty easy to come by in the UK as you mentioned. I personally like to cycle the dose to try to mimic the natural cycle but there are many ways to dose it. I use a 30 mg of the transdermal cream from days 11-21 and then 60-90 mg of cream from days 22-28 (or whenever menses begin). Doses are obviously higher if using the oral form as some is lost in the first pass through the liver. If you take a look at the links and find some products that you think might work for you, feel free to reply if you'd like my opinion...some days I feel like I've tried them all before settling on a regime that seems to be working (knock wood!).