Discussion in 'XMRV Research and Replication Studies' started by natasa778, Mar 6, 2010.
Thanks Warbler for finding this.... interesting...
There is a study that shows that RT is produced by some activated HERVs. And we know HERVs are active in CFS. I have quoted that study somewhere on the forum, sorry don't have that link handy.
Very interesting! Thank you all for bringing this to our attention and elaborating!
Here's another study that seems to say that another RV, HTLV-1, is sometimes associated with Sjorgens.
I've always had a sed rate of 0, 1 and 2. I also think it would be nice to have it mentioned in diagnostic guidelines as one piece among many to consider when diagnosing.
Osler's Web did note that some of the Tahoe cohort had nonmalignant (sometimes large) parotid salivary gland tumors. Also Burkitt's lymphoma (one of the normally rare b cell lymphomas associated with ME/CFIDS) often shows up as a malignant salivary gland tumor.
Finally, I, and many ME patients are thirsty all the time (due probably partly to 'dryness' in mouth) and pee a lot at night. We, including me, also get abscessed teeth alot (probably partly due to mouth dryness).
snap up half the night teeth abscessed so had that I had a number of extraactions because I would not respond to antibiotics.The dentist was totally baffled
if xmrv in latent phase then no reverse transcriptase
the sensitivity of the rt assay is about 100virions per ml not foolproof but pretty dammed sensitive
that review paper says it does get confused with some endogenous enzymes (but that RT PCR technique eliminates this risk). And it also says that it is produced by ERVs - I haven't had time to read the papers they are referencing for this, if anyone does pls post
endo retros dont produce rt in vivo. it is possible to manipulate certain cell lines to obtain expression of the enzyme partcularily from hervs within mitochondrial DNA which is also prokaryotic in nature.Hervs can and do express proteins assocated with pathology but there is no evidence of RT
I have those fluid balance problems. Up all night peeing etc. In my case it is due to low ADH. This is a common finding according to dr shoemaker and is in his list of diagnostic criteria. It can be an absolute or a relative low level so osmolarity and adh are tested at the same time. Low or wildly fluctuating adh levels are seen as indicating hypothalamic damage. I think low adh is also sometimes seen in head injury cases.
I used to be healthy as a horse but 2 weeks after an exposure (sexual intercourse/oral sex) in February 2012 I had an infection (including a swollen cervical node). About 4 months post exposure (June 2012) I started with dry mouth problems. Currently (July 2015) I am being treated as if I have Sjogren due severe salivary gland dysfunction which causes me xerostomia. My serologic tests including HIV, HTLV, HBV, HBC are all negative, and reumatoid tests (ANA, etc.) are negative.
Photos of my tongue
Pretty sure I contracted an unknown virus -probably a retrovirus, because retroviruses have been linked to salivary gland disease. If anyone is in a similar case, please advise. I don't have other symptoms (pain, fatigue, etc.)
You can also try a Google Site Search
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