https://www.sciencedaily.com/releases/2016/07/160727140041.htm Resveratrol, given to Alzheimer's patients, appears to restore the integrity of the blood-brain barrier, reducing the ability of harmful immune molecules secreted by immune cells to infiltrate from the body into brain tissues, say researchers. The reduction in neuronal inflammation slowed the cognitive decline of patients, compared to a matching group of placebo-treated patients with the disorder. ... Previous studies with animals found that age-related diseases--including Alzheimer's -- can be prevented or delayed by long-term caloric restriction (consuming two-thirds the normal caloric intake). The researchers studied resveratrol because it mimics the effects of caloric restriction by also activating proteins called sirtuins. ,,, These new findings support the notion that resveratrol decreases swelling that results from inflammation in Alzheimer's brain," says Turner. "This seemingly paradoxical effect is also found with many of the drugs that are beneficial for patients with multiple sclerosis -- another brain disease characterized by excessive inflammation."