Hi, I got my results back, currently taking 500 mcg for about 2 weeks now, split in morning and early afternoon. prior to that 250mcg a day for about a month. Sleep has been good (but only when taking just mb12), but yesterday just started mfolate again at 200mcg in the morning, I am so sensitive to this stuff, did not sleep last night, legs tingling, multiple wake ups. Any way I would be grateful for any pointers, observation, what not to do etc, my results: +/+ VDR Taq, MAO-1 R297R, BHMT-02, BHMT-08 +/- MTHFR C677T,COMT V158M,COMT H62H,ACAT1-02,MTR A2756G,MTRR A66G, MTRR K350A, MTRR A664A,CBS C699T & A360A, VDR fok (FF) I have read Caledonia's excellent SNPs guide but it's like rocket science, my brain hurts! Thanks for your help!!!