Marco , I have been suggesting antioxidant protocols for fifteen years now, and presented a paper on this to the 1999 CFS conference in Sydney. Marty Pall has been using these since the 1990s. The methylation protocol was found to be of some benefit in Rich's study. There is no question many of us benefit from these supplements and changes in diet to improve their intake and absorption. In particular I regularly discuss the antioxidant pentet, and I am currently testing resveratrol to good effect.
CoQ10 in particular is deficient in many of us and is critical to mitochondrial function. Again, like glutathione, if we have some but not enough we might be able to function at a low level, but trying to raise functional capacity (e.g. during exercise) will see us hitting a wall.
In practical terms the only CoQ10 I ever responded to is EnQten. It is no longer made in this part of the world though, which has been a problem for me. I have tried a few other brands locally, and a couple that were highly recommended from the US, but I don't feel any different on them.
Antioxidant protocols are perhaps the most common protocols ever used in ME. I recommend trying them, but I also think we should be aware they do not cure the condition. However if someone is on the way to natural recovery I think they can assist us, and there is a chance they might help prevent damage from OS and NS.