Choline on the Brain? A Guide to Choline in Chronic Fatigue Syndrome
http://phoenixrising.me/research-2/the-brain-in-chronic-fatigue-syndrome-mecfs/choline-on-the-brain-a-guide-to-choline-in-chronic-fatigue-syndrome-by-cort-johnson-aug-2005
Discuss the article on the Forums.

Research update from Prof. Ron Davis (video!)

Discussion in 'Latest ME/CFS Research' started by Ben H, Dec 20, 2017.

  1. drob31

    drob31 Senior Member

    Messages:
    1,273
    Likes:
    745

    I had the "standard" test for this and it was negative. Although the cyrex autoimmune panel was a weak positive.

    However it seems like some people have a ton of false positives with Cyrex.
     
  2. gregh286

    gregh286 Senior Member

    Messages:
    646
    Likes:
    929
    Londonderry, Northern Ireland.
    Looking at symptoms its easily and highly conceivable that blood flow in capillaries is not efficient. Numb hands..cold feet....ashen faced...weak pulse...muscle weakness....its endless.
    Lot of these symtoms are similar to very low taurine. Responsible for maintaining cell volume..membrane flexibility....electrolyte homestatis..
    Quite a few people here get real thirsty in bad crashes myself included. Water in just gets dumped out almost instantly via urine.
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2269780/
     
    Last edited: Jan 1, 2018
    Abrin, pattismith, Mel9 and 2 others like this.
  3. drob31

    drob31 Senior Member

    Messages:
    1,273
    Likes:
    745
    Do you think supplemental taurine would help? At what dose though?
     
  4. aquariusgirl

    aquariusgirl Senior Member

    Messages:
    1,492
    Likes:
    483
    Pretty sure yasko found all her CFS patients had high taurine in urine amino acids.

    Wasting taurine?
     
  5. RWP (Rest without Peace)

    RWP (Rest without Peace)

    Messages:
    60
    Likes:
    104
    @drob31, @aquariusgirl

    Yes, supplemental taurine could help in many areas. Usually, a 500 mg. dose would be the place to start, though if someone is very sensitive, a partial amount of that could be used.

    @aquariusgirl, if those values are correct (high taurine output), that makes sense. Over the 30 years of my wife's [@PWR (Peace without Rest)] illness, she has used taurine for detoxing after chemical exposures (due to MCS) and for sleep. Right now, she can tolerate large doses (5 grams or more per night), or maybe she's wasting so much, she's using it up too fast!

    Unlike other sleep-inducing amino acids, taurine doesn't cause much the typical grogginess. It's also a key component of bile, and if my memory serves me, Dr. Naviaux found a deficiency of bile metabolites in the Severely Ill study.

    P.S. I just added this: If using taurine for sleep, be aware that (in large doses) it will stimulate bile and urine flow, so use only what's necessary to avoid unintended bodily functions at bedtime. :)

    @RWP + PWR
     
    Last edited: Jan 1, 2018
    TreePerson and ljimbo423 like this.
  6. charityfundraiser

    charityfundraiser Senior Member

    Messages:
    127
    Likes:
    40
    SF Bay Area
    In the beginning of my illness when I was more severe, when I had blood drawn, I saw that the color of my blood was first a rusty brown orange, then a milky purple and glopped out of the line into the tube with the consistency of a blueberry yogurt drink. I sat there looking at that and wondered how I was alive. Later the color and consistency turned back to something that looked normal although I wasn't that much less severe and I don't know if it had to do with any treatments I tried.
     
  7. gregh286

    gregh286 Senior Member

    Messages:
    646
    Likes:
    929
    Londonderry, Northern Ireland.
    Yea i just started taking taurine again. 5g a day.
    Looking back on my amino profile i was borderline low on taurine. 103 against 80-545
     
    Last edited: Jan 2, 2018
  8. anni66

    anni66 mum to ME daughter

    Messages:
    280
    Likes:
    1,027
    scotland
    Yes - same with the autoantibody proposal by Prof Behan in 1980s- now being reconsidered. ... Research is also limited by the tools available to test such theories, we have a different level of equipment now - hopefully this will yield results that can inform actual treatment options
     
  9. aquariusgirl

    aquariusgirl Senior Member

    Messages:
    1,492
    Likes:
    483

    Blood, urine?
     
  10. gregh286

    gregh286 Senior Member

    Messages:
    646
    Likes:
    929
    Londonderry, Northern Ireland.
    Urine fmv. Genova. Range is 80-545 not 101-540 as i wrote.
     
  11. aquariusgirl

    aquariusgirl Senior Member

    Messages:
    1,492
    Likes:
    483
    Not sure how useful urine is... I was just talking to my doc about this...you could be wasting it..or. can't remember the full explanation.

    I think you need blood and urine at the same time.....
     
  12. gregh286

    gregh286 Senior Member

    Messages:
    646
    Likes:
    929
    Londonderry, Northern Ireland.
    Prehaps. This was done a few years back. You know how it is when you get cfs. You believe if you do enough tests something gives. Clutching straws at will or a fishing expedition :)
     
  13. ash0787

    ash0787 Senior Member

    Messages:
    308
    Likes:
    585
    I get the opposite, overly strong pulse which is rarely ever seeming 'normal', sometimes it makes it hard to go to sleep, and the rate is usually 10% + more than normal, 20 to 30% quite often, on rare occasions though its 75%+ faster, which I call 'POTS'. These things should be detectable by standard equipment but when doctors have used a stethoscope they don't seem to notice a difference. Also this is while taking beta blockers so god knows what it would be like without.
     
  14. gregh286

    gregh286 Senior Member

    Messages:
    646
    Likes:
    929
    Londonderry, Northern Ireland.
    Yeah i get that also. One extreme to other. Tend to get faster HR after carby meals. Can happen in middle of night too with night sweats....can be quite unnerving to say the least.
    Feels as if body drifts into panic mode.. like adrenaline surge or whatever.. The long list of non exhaustive symtoms eh....
     
  15. Nine lives

    Nine lives

    Messages:
    9
    Likes:
    16

    I have had blood draws where I look at blood vials and think blood slightly strange color (to the point I think to myself this does not look healthy). I noticed a cool red, darker than normal ( I am artist so attuned to color). Interesting, I found there is a condition called methemoglobinemia, where the iron has been changed from +2 to +3, which inhibits hemoglobin transporting oxygen. What caught my eye for the acquired form was some of chemical triggers are benzene derived. MCS tigger for me. Not sure is this is related but I have a huge problem with benzoate's also.
     
  16. Awags1986

    Awags1986

    Messages:
    48
    Likes:
    46
    Ohio
    My uncle passed away from complications of what they believed to be Auto Immune hemolytic Anemia that was unresponsive to medications....Is that similar to DIC? His hemoglobin was 6 at one point...
     
  17. ljimbo423

    ljimbo423 Senior Member

    Messages:
    657
    Likes:
    1,063
    United States, New Hampshire
    Hi Awags1986- Sorry, I really don't know any more about blood clotting disorders than the little I read, when I was reading about sepsis.:)

    Jim
     
  18. gregh286

    gregh286 Senior Member

    Messages:
    646
    Likes:
    929
    Londonderry, Northern Ireland.
    My father.in law had that last year. Treated successfully with rituximab.
    His colour (palor) was awful other than that he didnt really know he had anything wrong..just a little.more tired.
     
    Awags1986 likes this.
  19. bertiedog

    bertiedog Senior Member

    Messages:
    1,033
    Likes:
    1,459
    South East England, UK
    I have been taking a daily low dose of Propananol with good effects since around 2000. It always makes me feel a bit better without side effects. At the moment its only 10 mg first thing in the morning but when it gets hot I need another dose.

    Pam
     
  20. Awags1986

    Awags1986

    Messages:
    48
    Likes:
    46
    Ohio
    Thank goodness he responded to medications! My uncle was at a small community hospital outside of Detroit, and I honestly feel that if he had been somewhere like U of M that it wouldn't have all gone downhill so quickly :(
     

See more popular forum discussions.

Share This Page