Severe ME Day of Understanding and Remembrance: Aug. 8, 2017
Determined to paper the Internet with articles about ME, Jody Smith brings some additional focus to Severe Myalgic Encephalomyelitis Day of Understanding and Remembrance on Aug. 8, 2017 ...
Discuss the article on the Forums.

Research Document - Anybody Knows What It Is?

Discussion in 'XMRV Research and Replication Studies' started by shannah, Jan 2, 2011.

  1. shannah

    shannah Senior Member

    Messages:
    1,366
    Likes:
    1,638
    This document keeps coming back to haunt me. Can one of the scientific minds here please take a look at this and tell me what it actually represents.

    It's the very last page and easy to quickly scroll to in this latest patent application from Mikovits/Lombardi/Ruscetti's. Apparently this is a phylogenetic tree and it lists 28 entities subdivided into different categories. Do you think this indicates that they've discovered 28 different variants of X and P ????

    If not, what does it represent? If you honestly don't know, please say so.

    http://www.wipo.int/pctdb/images4/PCT-PAGES/2010/512010/10148323/10148323.pdf
     
  2. Sam Carter

    Sam Carter Guest

    Messages:
    316
    Likes:
    363
    I honestly don't know (for sure, at least) but from reading the patent the phylogenetic tree at the end of the document is to demonstrate that the fully-sequenced viral isolates found by the WPI do not cluster with mouse endogenous retroviruses and are therefore not lab contaminants.

    from p57
    """""""""""""""""""""""
    EXAMPLE 21: PHYLOGENETIC ANALYSIS

    [0270] To exclude the possibility of detecting
    a murine leukemia virus (MLV) laboratory
    contaminant, the phylogenetic relationship
    among endogenous (non-ecotropic) MLV sequences,
    XMRV sequences, and sequences for CFS subjects
    1104,1106 and 1178 was determined.

    ...

    [0272] Results showed that XMRV sequences from
    the CFS subjects clustered with the XMRV
    sequences from prostate cancer cases and formed
    a branch distinct from non-ecotropic MLVs
    common in inbred mouse strains (see e.g. FIG 13).

    [0273] Thus, the virus detected in the CFS
    subjects' blood samples is unlikely to be a
    contaminant.
    """""""""""""""""""""""
     
  3. shannah

    shannah Senior Member

    Messages:
    1,366
    Likes:
    1,638
    Oh Sam - Thank you. That now makes sense.

    Tonight I zeroed in on page 11 where it states:

    "[0047] Fig. 13 is diagram depicting the phylogenetic relationship among endogenous (non-ecotropic) MLV sequences, XMRV sequences, and sequences from CFS subjects 1104, 1106, and 1178. Further details regarding methodology are provided in Example 21."

    So you've put the whole puzzle together here for me.

    Thanks again!
     
  4. LJS

    LJS Insert Witty Comment Here

    Messages:
    207
    Likes:
    7
    East Coast, USA
  5. shannah

    shannah Senior Member

    Messages:
    1,366
    Likes:
    1,638
    Thanks LJS - appreciate the link.
     
  6. Merry

    Merry Senior Member

    Messages:
    1,358
    Likes:
    623
    Columbus, Ohio, USA
    Thanks for this and for all the interesting info you find and post. I'm grateful to you for your dedication.
     
  7. shannah

    shannah Senior Member

    Messages:
    1,366
    Likes:
    1,638
    Gee - thanks Merry.

    Are we likely to see more of those turnip little cuties soon?
     
  8. Merry

    Merry Senior Member

    Messages:
    1,358
    Likes:
    623
    Columbus, Ohio, USA
    I can't tell you how I'm flattered to have my name linked with "turnip little cuties." But helen41, the creator of the videos, is the one you'll have to ask. When I myself asked Helen about what the future was likely to hold for the turnips, she responded, "Compost."
     
  9. shannah

    shannah Senior Member

    Messages:
    1,366
    Likes:
    1,638
    Obviously I'm confused - sorry Merry. Seems I remember your name as being a major cheerleader though.
     

See more popular forum discussions.

Share This Page