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Reporting of financial conflicts of interest in clinical practice guidelines

Discussion in 'Other Health News and Research' started by Denise, Aug 22, 2016.

  1. Denise

    Denise Senior Member

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    Haven't had a chance to read this yet but thought some folks here might also be interested in it.
    "Reporting of financial conflicts of interest in clinical practice guidelines: a case study analysis of guidelines from the Canadian Medical Association Infobase
    • Adrienne ShnierEmail author,
    • Joel Lexchin,
    • Mirna Romero and
    • Kevin Brown
    Abstract
    Background
    Clinical practice guidelines are widely distributed by medical associations and relied upon by physicians for the best available clinical evidence. International findings report that financial conflicts of interest (FCOI) with drug companies may influence drug recommendations and are common among guideline authors. There is no comparable study on exclusively Canadian guidelines; therefore, we provide a case study of authors’ FCOI declarations in guidelines from the Canadian Medical Association (CMA) Infobase. We also assess the financial relationships between guideline-affiliated organizations and drug companies.

    Methods
    Using a population approach, we extracted first-line drug recommendations and authors’ FCOI disclosures in guidelines from the CMA Infobase. We contacted the corresponding authors on guidelines when FCOI disclosures were missing for some or all authors. We also extracted guideline-affiliated organizations and searched each of their websites to determine if they had financial relationships with drug companies.

    Results
    We analyzed 350 authors from 28 guidelines. Authors were named on one, two, or three guidelines, yielding 400 FCOI statements. In 75.0 % of guidelines at least one author, and in 21.4 % of guidelines all authors, disclosed FCOI with drug companies. In 54.0 % of guidelines at least one author, and in 28.6 % of guidelines over half of the authors, disclosed FCOI with manufacturers of drugs that they recommended. Twenty of 48 authors on multiple guidelines reported different FCOI in their disclosures. Eight guidelines identified affiliated organizations with financial relationships with manufacturers of drugs recommended in those guidelines.

    Conclusions
    This is the first study to systematically describe FCOI disclosures by authors of Canadian guidelines and financial relationships between guideline-affiliated organizations and pharmaceutical companies. These financial relationships are common. Because authoritative value is assigned to guidelines distributed by medical associations, we encourage them to develop formal policies to limit the potential influence of FCOI on guideline recommendations."
     
    Valentijn, TiredSam, GreyOwl and 2 others like this.
  2. Dolphin

    Dolphin Senior Member

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  3. GreyOwl

    GreyOwl Dx: strong belief system, avoidance, hypervigilant

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    I would like to see conflict of interest statements include disclosures by authors of their financial relationships with insurance companies (life, medical, etc.), if they exist.

    I wonder there is a statistically significant association between those who subscribe to the school of BPS and acceptance of funds in any capacity from insurance companies or their subsidiaries?
     
    Valentijn, BruceInOz and Dolphin like this.

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